Nucleoside diphosphate kinase 3 (NDK 3) (NDP kinase 3) (EC 2.7.4.6) (DR-nm23) (Nucleoside diphosphate kinase C) (NDPKC) (nm23-H3)
1_MICLV 6_ LTIFA 11_ NLFPA 16_ ACTGA 21_ HERTF 26_ LAVKP 31_ DGVQR 36_ RLVGE 41_ IVRRF 46_ ERKGF 51_ KLVAL 56_ KLVQA 61_ SEELL 66_ REHYA 71_ ELRER 76_ PFYGR 81_ LVKYM 86_ ASGPV 91_ VAMVW 96_ QGLDV 101_ VRTSR 106_ ALIGA 111_ TNPAD 116_ APPGT 121_ IRGDF 126_ CIEVG 131_ KNLIH 136_ GSDSV 141_ ESARR 146_ EIALW 151_ FRADE 156_ LLCWE 161_DSAGH
1: Catalyzes the phosphorylation of ribonucleosides and deoxyribonucleoside diphosphates, other than ATP, into the corresponding triphosphates with ATP as the major phosphate donor (PubMed:11277919, PubMed:30587587). The ATP gamma phosphate is transferred to the nucleoside diphosphate beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:11277919, PubMed:30587587). Inhibits granulocyte differentiation (PubMed:7638209). May be required for ciliary function during renal development (By similarity)
2: Independently of its kinase activity, facilitates mitochondrial tethering prior to membrane fusion through its direct membrane-binding and hexamerization (PubMed:30587587, PubMed:37584589). Implicated in repair of both single- and double-stranded breaks in DNA through its association with the ribonucleotide reductase complex (RNR complex) via its interaction with the histone acetyltransferase KAT5, this interaction enables recruitment of NME3 at DNA damage sites where it plays a role in the repair of DNA, independently of its kinase activity (PubMed:37584589)