Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1)
1_MAAAA 6_ GNRAS 11_ SSGFP 16_ GARAT 21_ SPEAG 26_ GGGGA 31_ LKASS 36_ APAAA 41_ AGLLR 46_ EAGSG 51_ GRERA 56_ DWRRR 61_ QLRKV 66_ RSVEL 71_ DQLPE 76_ QPLFL 81_ AASPP 86_ ASSTS 91_ PSPEP 96_ ADAAG 101_ SGTGF 106_ QPVAV 111_ PPPHG 116_ AASRG 121_ GAHLT 126_ ESVAA 131_ PDSGA 136_ SSPAA 141_ AEPGE 146_ KRAPA 151_ AEPSP 156_ AAAPA 161_ GREME 166_ NKETL 171_ KGLHK 176_ MDDRP 181_ EERMI 186_ REKLK 191_ ATCMP 196_ AWKHE 201_ WLERR 206_ NRRGP 211_ VVVKP 216_ IPVKG 221_ DGSEM 226_ NHLAA 231_ ESPGE 236_ VQASA 241_ ASPAS 246_ KGRRS 251_ PSPGN 256_ SPSGR 261_ TVKSE 266_ SPGVR 271_ RKRVS 276_ PVPFQ 281_ SGRIT 286_ PPRRA 291_ PSPDG 296_ FSPYS 301_ PEETN 306_ RRVNK 311_ VMRAR 316_ LYLLQ 321_ QIGPN 326_ SFLIG 331_ GDSPD 336_ NKYRV 341_ FIGPQ 346_ NCSCA 351_ RGTFC 356_ IHLLF 361_ VMLRV 366_ FQLEP 371_ SDPML 376_ WRKTL 381_ KNFEV 386_ ESLFQ 391_ KYHSR 396_ RSSRI 401_ KAPSR 406_ NTIQK 411_ FVSRM 416_ SNSHT 421_ LSSSS 426_ TSTSS 431_ SENSI 436_ KDEEE 441_ QMCPI 446_ CLLGM 451_ LDEES 456_ LTVCE 461_ DGCRN 466_ KLHHH 471_ CMSIW 476_ AEECR 481_ RNREP 486_ LICPL 491_ CRSKW 496_ RSHDF 501_ YSHEL 506_ SSPVD 511_ SPSSL 516_ RAAQQ 521_ QTVQQ 526_ QPLAG 531_ SRRNQ 536_ ESNFN 541_ LTHYG 546_ TQQIP 551_ PAYKD 556_ LAEPW 561_ IQVFG 566_ MELVG 571_ CLFSR 576_ NWNVR 581_ EMALR 586_ RLSHD 591_ VSGAL 596_ LLANG 601_ ESTGN 606_ SGGSS 611_ GSSPS 616_ GGATS 621_ GSSQT 626_ SISGD 631_ VVEAC 636_ CSVLS 641_ MVCAD 646_ PVYKV 651_ YVAAL 656_ KTLRA 661_ MLVYT 666_ PCHSL 671_ AERIK 676_ LQRLL 681_ QPVVD 686_ TILVK 691_ CADAN 696_ SRTSQ 701_ LSIST 706_ LLELC 711_ KGQAG 716_ ELAVG 721_ REILK 726_ AGSIG 731_ IGGVD 736_ YVLNC 741_ ILGNQ 746_ TESNN 751_ WQELL 756_ GRLCL 761_ IDRLL 766_ LEFPA 771_ EFYPH 776_ IVSTD 781_ VSQAE 786_ PVEIR 791_ YKKLL 796_ SLLTF 801_ ALQSI 806_ DNSHS 811_ MVGKL 816_ SRRIY 821_ LSSAR 826_ MVTTV 831_ PHVFS 836_ KLLEM 841_ LSVSS 846_ STHFT 851_ RMRRR 856_ LMAIA 861_ DEVEI 866_ AEAIQ 871_ LGVED 876_ TLDGQ 881_ QDSFL 886_ QASVP 891_ NNYLE 896_ TTENS 901_ SPECT 906_ VHLEK 911_ TGKGL 916_ CATKL 921_ SASSE 926_ DISER 931_ LASIS 936_ VGPSS 941_ STTTT 946_ TTTTE 951_ QPKPM 956_ VQTKG 961_ RPHSQ 966_ CLNSS 971_ PLSHH 976_ SQLMF 981_ PALST 986_ PSSST 991_ PSVPA 996_ GTATD 1001_ VSKHR 1006_ LQGFI 1011_ PCRIP 1016_ SASPQ 1021_ TQRKF 1026_ SLQFH 1031_ RNCPE 1036_ NKDSD 1041_ KLSPV 1046_ FTQSR 1051_ PLPSS 1056_ NIHRP 1061_ KPSRP 1066_ TPGNT 1071_ SKQGD 1076_ PSKNS 1081_ MTLDL 1086_ NSSSK 1091_ CDDSF 1096_ GCSSN 1101_ SSNAV 1106_ IPSDE 1111_ TVFTP 1116_ VEEKC 1121_ RLDVN 1126_ TELNS 1131_ SIEDL 1136_ LEASM 1141_ PSSDT 1146_ TVTFK 1151_ SEVAV 1156_ LSPEK 1161_ AENDD 1166_ TYKDD 1171_ VNHNQ 1176_ KCKEK 1181_ MEAEE 1186_ EEALA 1191_ IAMAM 1196_ SASQD 1201_ ALPIV 1206_ PQLQV 1211_ ENGED 1216_ IIIIQ 1221_ QDTPE 1226_ TLPGH 1231_ TKAKQ 1236_ PYRED 1241_ TEWLK 1246_ GQQIG 1251_ LGAFS 1256_ SCYQA 1261_ QDVGT 1266_ GTLMA 1271_ VKQVT 1276_ YVRNT 1281_ SSEQE 1286_ EVVEA 1291_ LREEI 1296_ RMMSH 1301_ LNHPN 1306_ IIRML 1311_ GATCE 1316_ KSNYN 1321_ LFIEW 1326_ MAGGS 1331_ VAHLL 1336_ SKYGA 1341_ FKESV 1346_ VINYT 1351_ EQLLR 1356_ GLSYL 1361_ HENQI 1366_ IHRDV 1371_ KGANL 1376_ LIDST 1381_ GQRLR 1386_ IADFG 1391_ AAARL 1396_ ASKGT 1401_ GAGEF 1406_ QGQLL 1411_ GTIAF 1416_ MAPEV 1421_ LRGQQ 1426_ YGRSC 1431_ DVWSV 1436_ GCAII 1441_ EMACA 1446_ KPPWN 1451_ AEKHS 1456_ NHLAL 1461_ IFKIA 1466_ SATTA 1471_ PSIPS 1476_ HLSPG 1481_ LRDVA 1486_ LRCLE 1491_ LQPQD 1496_ RPPSR 1501_ ELLKH 1506_PVFRT
1: Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624)