cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII)
1_MGNGS 6_ VKPKH 11_ SKHPD 16_ GHSGN 21_ LTTDA 26_ LRNKV 31_ TELER 36_ ELRRK 41_ DAEIQ 46_ EREYH 51_ LKELR 56_ EQLSK 61_ QTVAI 66_ AELTE 71_ ELQNK 76_ CIQLN 81_ KLQDV 86_ VHMQG 91_ GSPLQ 96_ ASPDK 101_ VPLEV 106_ HRKTS 111_ GLVSL 116_ HSRRG 121_ AKAGV 126_ SAEPT 131_ TRTYD 136_ LNKPP 141_ EFSFE 146_ KARVR 151_ KDSSE 156_ KKLIT 161_ DALNK 166_ NQFLK 171_ RLDPQ 176_ QIKDM 181_ VECMY 186_ GRNYQ 191_ QGSYI 196_ IKQGE 201_ PGNHI 206_ FVLAE 211_ GRLEV 216_ FQGEK 221_ LLSSI 226_ PMWTT 231_ FGELA 236_ ILYNC 241_ TRTAS 246_ VKAIT 251_ NVKTW 256_ ALDRE 261_ VFQNI 266_ MRRTA 271_ QARDE 276_ QYRNF 281_ LRSVS 286_ LLKNL 291_ PEDKL 296_ TKIID 301_ CLEVE 306_ YYDKG 311_ DYIIR 316_ EGEEG 321_ STFFI 326_ LAKGK 331_ VKVTQ 336_ STEGH 341_ DQPQL 346_ IKTLQ 351_ KGEYF 356_ GEKAL 361_ ISDDV 366_ RSANI 371_ IAEEN 376_ DVACL 381_ VIDRE 386_ TFNQT 391_ VGTFE 396_ ELQKY 401_ LEGYV 406_ ANLNR 411_ DDEKR 416_ HAKRS 421_ MSNWK 426_ LSKAL 431_ SLEMI 436_ QLKEK 441_ VARFS 446_ SSSPF 451_ QNLEI 456_ IATLG 461_ VGGFG 466_ RVELV 471_ KVKNE 476_ NVAFA 481_ MKCIR 486_ KKHIV 491_ DTKQQ 496_ EHVYS 501_ EKRIL 506_ EELCS 511_ PFIVK 516_ LYRTF 521_ KDNKY 526_ VYMLL 531_ EACLG 536_ GELWS 541_ ILRDR 546_ GSFDE 551_ PTSKF 556_ CVACV 561_ TEAFD 566_ YLHRL 571_ GIIYR 576_ DLKPE 581_ NLILD 586_ AEGYL 591_ KLVDF 596_ GFAKK 601_ IGSGQ 606_ KTWTF 611_ CGTPE 616_ YVAPE 621_ VILNK 626_ GHDFS 631_ VDFWS 636_ LGILV 641_ YELLT 646_ GNPPF 651_ SGVDQ 656_ MMTYN 661_ LILKG 666_ IEKMD 671_ FPRKI 676_ TRRPE 681_ DLIRR 686_ LCRQN 691_ PTERL 696_ GNLKN 701_ GINDI 706_ KKHRW 711_ LNGFN 716_ WEGLK 721_ ARSLP 726_ SPLQR 731_ ELKGP 736_ IDHSY 741_ FDKYP 746_ PEKGM 751_ PPDEL 756_SGWDK
1: Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (PubMed:33106379). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as a regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity)