Src-like-adapter (Src-like-adapter protein 1) (SLAP-1) (hSLAP)
1_MGNSM 6_ KSTPA 11_ PAERP 16_ LPNPE 21_ GLDSD 26_ FLAVL 31_ SDYPS 36_ PDISP 41_ PIFRR 46_ GEKLR 51_ VISDE 56_ GGWWK 61_ AISLS 66_ TGRES 71_ YIPGI 76_ CVARV 81_ YHGWL 86_ FEGLG 91_ RDKAE 96_ ELLQL 101_ PDTKV 106_ GSFMI 111_ RESET 116_ KKGFY 121_ SLSVR 126_ HRQVK 131_ HYRIF 136_ RLPNN 141_ WYYIS 146_ PRLTF 151_ QCLED 156_ LVNHY 161_ SEVAD 166_ GLCCV 171_ LTTPC 176_ LTQST 181_ AAPAV 186_ RASSS 191_ PVTLR 196_ QKTVD 201_ WRRVS 206_ RLQED 211_ PEGTE 216_ NPLGV 221_ DESLF 226_ SYGLR 231_ ESIAS 236_ YLSLT 241_ SEDNT 246_ SFDRK 251_ KKSIS 256_ LMYGG 261_ SKRKS 266_ SFFSS 271_PPYFE
1: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins