Prostaglandin D2 receptor (PGD receptor) (PGD2 receptor) (Prostanoid DP receptor)
1_MKSPF 6_ YRCQN 11_ TTSVE 16_ KGNSA 21_ VMGGV 26_ LFSTG 31_ LLGNL 36_ LALGL 41_ LARSG 46_ LGWCS 51_ RRPLR 56_ PLPSV 61_ FYMLV 66_ CGLTV 71_ TDLLG 76_ KCLLS 81_ PVVLA 86_ AYAQN 91_ RSLRV 96_ LAPAL 101_ DNSLC 106_ QAFAF 111_ FMSFF 116_ GLSST 121_ LQLLA 126_ MALEC 131_ WLSLG 136_ HPFFY 141_ RRHIT 146_ LRLGA 151_ LVAPV 156_ VSAFS 161_ LAFCA 166_ LPFMG 171_ FGKFV 176_ QYCPG 181_ TWCFI 186_ QMVHE 191_ EGSLS 196_ VLGYS 201_ VLYSS 206_ LMALL 211_ VLATV 216_ LCNLG 221_ AMRNL 226_ YAMHR 231_ RLQRH 236_ PRSCT 241_ RDCAE 246_ PRADG 251_ REASP 256_ QPLEE 261_ LDHLL 266_ LLALM 271_ TVLFT 276_ MCSLP 281_ VIYRA 286_ YYGAF 291_ KDVKE 296_ KNRTS 301_ EEAED 306_ LRALR 311_ FLSVI 316_ SIVDP 321_ WIFII 326_ FRSPV 331_ FRIFF 336_ HKIFI 341_ RPLRY 346_ RSRCS 351_NSTNM
1: Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity)