Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)
1_MAASA 6_ AAASA 11_ AAASA 16_ ASGSP 21_ GPGEG 26_ SAGGE 31_ KRSTA 36_ PSAAA 41_ SASAS 46_ AAASS 51_ PAGGG 56_ AEALE 61_ LLEHC 66_ GVCRE 71_ RLRPE 76_ REPRL 81_ LPCLH 86_ SACSA 91_ CLGPA 96_ APAAA 101_ NSSGD 106_ GGAAG 111_ DGTVV 116_ DCPVC 121_ KQQCF 126_ SKDIV 131_ ENYFM 136_ RDSGS 141_ KAATD 146_ AQDAN 151_ QCCTS 156_ CEDNA 161_ PATSY 166_ CVECS 171_ EPLCE 176_ TCVEA 181_ HQRVK 186_ YTKDH 191_ TVRST 196_ GPAKS 201_ RDGER 206_ TVYCN 211_ VHKHE 216_ PLVLF 221_ CESCD 226_ TLTCR 231_ DCQLN 236_ AHKDH 241_ QYQFL 246_ EDAVR 251_ NQRKL 256_ LASLV 261_ KRLGD 266_ KHATL 271_ QKSTK 276_ EVRSS 281_ IRQVS 286_ DVQKR 291_ VQVDV 296_ KMAIL 301_ QIMKE 306_ LNKRG 311_ RVLVN 316_ DAQKV 321_ TEGQQ 326_ ERLER 331_ QHWTM 336_ TKIQK 341_ HQEHI 346_ LRFAS 351_ WALES 356_ DNNTA 361_ LLLSK 366_ KLIYF 371_ QLHRA 376_ LKMIV 381_ DPVEP 386_ HGEMK 391_ FQWDL 396_ NAWTK 401_ SAEAF 406_ GKIVA 411_ ERPGT 416_ NSTGP 421_ APMAP 426_ PRAPG 431_ PLSKQ 436_ GSGSS 441_ QPMEV 446_ QEGYG 451_ FGSGD 456_ DPYSS 461_ AEPHV 466_ SGVKR 471_ SRSGE 476_ GEVSG 481_ LMRKV 486_ PRVSL 491_ ERLDL 496_ DLTAD 501_ SQPPV 506_ FKVFP 511_ GSTTE 516_ DYNLI 521_ VIERG 526_ AAAAA 531_ TGQPG 536_ TAPAG 541_ TPGAP 546_ PLAGM 551_ AIVKE 556_ EETEA 561_ AIGAP 566_ PTATE 571_ GPETK 576_ PVLMA 581_ LAEGP 586_ GAEGP 591_ RLASP 596_ SGSTS 601_ SGLEV 606_ VAPEG 611_ TSAPG 616_ GGPGT 621_ LDDSA 626_ TICRV 631_ CQKPG 636_ DLVMC 641_ NQCEF 646_ CFHLD 651_ CHLPA 656_ LQDVP 661_ GEEWS 666_ CSLCH 671_ VLPDL 676_ KEEDG 681_ SLSLD 686_ GADST 691_ GVVAK 696_ LSPAN 701_ QRKCE 706_ RVLLA 711_ LFCHE 716_ PCRPL 721_ HQLAT 726_ DSTFS 731_ LDQPG 736_ GTLDL 741_ TLIRA 746_ RLQEK 751_ LSPPY 756_ SSPQE 761_ FAQDV 766_ GRMFK 771_ QFNKL 776_ TEDKA 781_ DVQSI 786_ IGLQR 791_ FFETR 796_ MNEAF 801_ GDTKF 806_ SAVLV 811_ EPPPM 816_ SLPGA 821_ GLSSQ 826_ELSGG
1: Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610)
2: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1