Dehydrogenase/reductase SDR family member 2, mitochondrial (EC 1.1.1.-) (Dicarbonyl reductase HEP27) (Protein D) (Short chain dehydrogenase/reductase family 25C member 1) (Protein SDR25C1)
1_MLSAV 6_ ARGYQ 11_ GWFHP 16_ CARLS 21_ VRMSS 26_ TGIDR 31_ KGVLA 36_ NRVAV 41_ VTGST 46_ SGIGF 51_ AIARR 56_ LARDG 61_ AHVVI 66_ SSRKQ 71_ QNVDR 76_ AMAKL 81_ QGEGL 86_ SVAGI 91_ VCHVG 96_ KAEDR 101_ EQLVA 106_ KALEH 111_ CGGVD 116_ FLVCS 121_ AGVNP 126_ LVGST 131_ LGTSE 136_ QIWDK 141_ ILSVN 146_ VKSPA 151_ LLLSQ 156_ LLPYM 161_ ENRRG 166_ AVILV 171_ SSIAA 176_ YNPVV 181_ ALGVY 186_ NVSKT 191_ ALLGL 196_ TRTLA 201_ LELAP 206_ KDIRV 211_ NCVVP 216_ GIIKT 221_ DFSKV 226_ FHGNE 231_ SLWKN 236_ FKEHH 241_ QLQRI 246_ GESED 251_ CAGIV 256_ SFLCS 261_ PDASY 266_ VNGEN 271_IAVAG
1: NADPH-dependent oxidoreductase which catalyzes the reduction of dicarbonyl compounds. Displays reductase activity in vitro with 3,4-hexanedione, 2,3-heptanedione and 1-phenyl-1,2-propanedione as substrates (PubMed:16685466). May function as a dicarbonyl reductase in the enzymatic inactivation of reactive carbonyls involved in covalent modification of cellular components (PubMed:16685466). Also displays a minor hydroxysteroid dehydrogenase activity toward bile acids such as ursodeoxycholic acid (UDCA) and isoursodeoxycholic acid (isoUDCA), which makes it unlikely to control hormone levels (PubMed:16685466). Doesn't show any activity in vitro with retinoids and sugars as substrates (PubMed:16685466). Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21 (PubMed:20547751). Reduces proliferation, migration and invasion of cancer cells and well as the production of ROS in cancer (PubMed:29106393)