Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1)
1_MVMEK 6_ PSPLL 11_ VGREF 16_ VRQYY 21_ TLLNQ 26_ APDML 31_ HRFYG 36_ KNSSY 41_ VHGGL 46_ DSNGK 51_ PADAV 56_ YGQKE 61_ IHRKV 66_ MSQNF 71_ TNCHT 76_ KIRHV 81_ DAHAT 86_ LNDGV 91_ VVQVM 96_ GLLSN 101_ NNQAL 106_ RRFMQ 111_ TFVLA 116_ PEGSV 121_ ANKFY 126_ VHNDI 131_ FRYQD 136_ EVFGG 141_ FVTEP 146_ QEESE 151_ EEVEE 156_ PEERQ 161_ QTPEV 166_ VPDDS 171_ GTFYD 176_ QAVVS 181_ NDMEE 186_ HLEEP 191_ VAEPE 196_ PDPEP 201_ EPEQE 206_ PVSEI 211_ QEEKP 216_ EPVLE 221_ ETAPE 226_ DAQKS 231_ SSPAP 236_ ADIAQ 241_ TVQED 246_ LRTFS 251_ WASVT 256_ SKNLP 261_ PSGAV 266_ PVTGI 271_ PPHVV 276_ KVPAS 281_ QPRPE 286_ SKPES 291_ QIPPQ 296_ RPQRD 301_ QRVRE 306_ QRINI 311_ PPQRG 316_ PRPIR 321_ EAGEQ 326_ GDIEP 331_ RRMVR 336_ HPDSH 341_ QLFIG 346_ NLPHE 351_ VDKSE 356_ LKDFF 361_ QSYGN 366_ VVELR 371_ INSGG 376_ KLPNF 381_ GFVVF 386_ DDSEP 391_ VQKVL 396_ SNRPI 401_ MFRGE 406_ VRLNV 411_ EEKKT 416_ RAARE 421_ GDRRD 426_ NRLRG 431_ PGGPR 436_ GGLGG 441_ GMRGP 446_ PRGGM 451_ VQKPG 456_ FGVGR 461_GLAPR
1: Protein involved in various processes, such as stress granule formation and innate immunity (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:30510222, PubMed:30804210). Plays an essential role in stress granule formation (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:35977029, PubMed:36183834, PubMed:36279435, PubMed:36692217, PubMed:37379838). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:36279435, PubMed:37379838). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:36279435, PubMed:36692217). Also acts as an ATP- and magnesium-dependent helicase: unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Plays an essential role in innate immunity by promoting CGAS and RIGI activity (PubMed:30510222, PubMed:30804210). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS (PubMed:30510222). Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles (PubMed:34779554). Also enhances RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (PubMed:30804210). May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro: Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510)