Steroidogenic factor 1 (SF-1) (STF-1) (hSF-1) (Adrenal 4-binding protein) (Fushi tarazu factor homolog 1) (Nuclear receptor subfamily 5 group A member 1) (Steroid hormone receptor Ad4BP)
1_MDYSY 6_ DEDLD 11_ ELCPV 16_ CGDKV 21_ SGYHY 26_ GLLTC 31_ ESCKG 36_ FFKRT 41_ VQNNK 46_ HYTCT 51_ ESQSC 56_ KIDKT 61_ QRKRC 66_ PFCRF 71_ QKCLT 76_ VGMRL 81_ EAVRA 86_ DRMRG 91_ GRNKF 96_ GPMYK 101_ RDRAL 106_ KQQKK 111_ AQIRA 116_ NGFKL 121_ ETGPP 126_ MGVPP 131_ PPPPA 136_ PDYVL 141_ PPSLH 146_ GPEPK 151_ GLAAG 156_ PPAGP 161_ LGDFG 166_ APALP 171_ MAVPG 176_ AHGPL 181_ AGYLY 186_ PAFPG 191_ RAIKS 196_ EYPEP 201_ YASPP 206_ QPGLP 211_ YGYPE 216_ PFSGG 221_ PNVPE 226_ LILQL 231_ LQLEP 236_ DEDQV 241_ RARIL 246_ GCLQE 251_ PTKSR 256_ PDQPA 261_ AFGLL 266_ CRMAD 271_ QTFIS 276_ IVDWA 281_ RRCMV 286_ FKELE 291_ VADQM 296_ TLLQN 301_ CWSEL 306_ LVFDH 311_ IYRQV 316_ QHGKE 321_ GSILL 326_ VTGQE 331_ VELTT 336_ VATQA 341_ GSLLH 346_ SLVLR 351_ AQELV 356_ LQLLA 361_ LQLDR 366_ QEFVC 371_ LKFII 376_ LFSLD 381_ LKFLN 386_ NHILV 391_ KDAQE 396_ KANAA 401_ LLDYT 406_ LCHYP 411_ HCGDK 416_ FQQLL 421_ LCLVE 426_ VRALS 431_ MQAKE 436_ YLYHK 441_ HLGNE 446_ MPRNN 451_ LLIEM 456_LQAKQ
1: Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation