Battenin (Batten disease protein) (Protein CLN3)
1_MGGCA 6_ GSRRR 11_ FSDSE 16_ GEETV 21_ PEPRL 26_ PLLDH 31_ QGAHW 36_ KNAVG 41_ FWLLG 46_ LCNNF 51_ SYVVM 56_ LSAAH 61_ DILSH 66_ KRTSG 71_ NQSHV 76_ DPGPT 81_ PIPHN 86_ SSSRF 91_ DCNSV 96_ STAAV 101_ LLADI 106_ LPTLV 111_ IKLLA 116_ PLGLH 121_ LLPYS 126_ PRVLV 131_ SGICA 136_ AGSFV 141_ LVAFS 146_ HSVGT 151_ SLCGV 156_ VFASI 161_ SSGLG 166_ EVTFL 171_ SLTAF 176_ YPRAV 181_ ISWWS 186_ SGTGG 191_ AGLLG 196_ ALSYL 201_ GLTQA 206_ GLSPQ 211_ QTLLS 216_ MLGIP 221_ ALLLA 226_ SYFLL 231_ LTSPE 236_ AQDPG 241_ GEEEA 246_ ESAAR 251_ QPLIR 256_ TEAPE 261_ SKPGS 266_ SSSLS 271_ LRERW 276_ TVFKG 281_ LLWYI 286_ VPLVV 291_ VYFAE 296_ YFINQ 301_ GLFEL 306_ LFFWN 311_ TSLSH 316_ AQQYR 321_ WYQML 326_ YQAGV 331_ FASRS 336_ SLRCC 341_ RIRFT 346_ WALAL 351_ LQCLN 356_ LVFLL 361_ ADVWF 366_ GFLPS 371_ IYLVF 376_ LIILY 381_ EGLLG 386_ GAAYV 391_ NTFHN 396_ IALET 401_ SDEHR 406_ EFAMA 411_ ATCIS 416_ DTLGI 421_ SLSGL 426_ LALPL 431_HDFLC
1: Mediates microtubule-dependent, anterograde transport connecting the Golgi network, endosomes, autophagosomes, lysosomes and plasma membrane, and participates in several cellular processes such as regulation of lysosomal pH, lysosome protein degradation, receptor-mediated endocytosis, autophagy, transport of proteins and lipids from the TGN, apoptosis and synaptic transmission (PubMed:10924275, PubMed:15471887, PubMed:18317235, PubMed:18817525, PubMed:20850431, PubMed:22261744). Facilitates the proteins transport from trans-Golgi network (TGN)-to other membrane compartments such as transport of microdomain-associated proteins to the plasma membrane, IGF2R transport to the lysosome where it regulates the CTSD release leading to regulation of CTSD maturation and thereby APP intracellular processing (PubMed:10924275, PubMed:18817525). Moreover regulates CTSD activity in response to osmotic stress (PubMed:23840424, PubMed:28390177). Also binds galactosylceramide and transports it from the trans Golgi to the rafts, which may have immediate and downstream effects on cell survival by modulating ceramide synthesis (PubMed:18317235). At the plasma membrane, regulates actin-dependent events including filopodia formation, cell migration, and pinocytosis through ARF1-CDC42 pathway and also the cytoskeleton organization through interaction with MYH10 and fodrin leading to the regulation of the plasma membrane association of Na+, K+ ATPase complex (PubMed:20850431). Regulates synaptic transmission in the amygdala, hippocampus, and cerebellum through regulation of synaptic vesicles density and their proximity to active zones leading to modulation of short-term plasticity and age-dependent anxious behavior, learning and memory (By similarity). Regulates autophagic vacuoles (AVs) maturation by modulating the trafficking between endocytic and autophagolysosomal/lysosomal compartments, which involves vesicle fusion leading to regulation of degradation process (By similarity). Also participates in cellular homeostasis of compounds such as, water, ions, amino acids, proteins and lipids in several tissue namely in brain and kidney through regulation of their transport and synthesis (PubMed:17482562)