N-myc-interactor (Nmi) (N-myc and STAT interactor)
1_MEADK 6_ DDTQQ 11_ ILKEH 16_ SPDEF 21_ IKDEQ 26_ NKGLI 31_ DEITK 36_ KNIQL 41_ KKEIQ 46_ KLETE 51_ LQEAT 56_ KEFQI 61_ KEDIP 66_ ETKMK 71_ FLSVE 76_ TPEND 81_ SQLSN 86_ ISCSF 91_ QVSSK 96_ VPYEI 101_ QKGQA 106_ LITFE 111_ KEEVA 116_ QNVVS 121_ MSKHH 126_ VQIKD 131_ VNLEV 136_ TAKPV 141_ PLNSG 146_ VRFQV 151_ YVEVS 156_ KMKIN 161_ VTEIP 166_ DTLRE 171_ DQMRD 176_ KLELS 181_ FSKSR 186_ NGGGE 191_ VDRVD 196_ YDRQS 201_ GSAVI 206_ TFVEI 211_ GVADK 216_ ILKKK 221_ EYPLY 226_ INQTC 231_ HRVTV 236_ SPYTE 241_ IHLKK 246_ YQIFS 251_ GTSKR 256_ TVLLT 261_ GMEGI 266_ QMDEE 271_ IVEDL 276_ INIHF 281_ QRAKN 286_ GGGEV 291_ DVVKC 296_ SLGQP 301_HIAYF
1: Acts as a signaling pathway regulator involved in innate immune system response (PubMed:26342464, PubMed:29038465, PubMed:29350881, PubMed:9989503). In response to interleukin 2/IL2 and interferon IFN-gamma/IFNG, interacts with signal transducer and activator of transcription/STAT which activate the transcription of downstream genes involved in a multitude of signals for development and homeostasis (PubMed:29377960, PubMed:9989503). Enhances the recruitment of CBP/p300 coactivators to STAT1 and STAT5, resulting in increased STAT1- and STAT5-dependent transcription (PubMed:9989503). In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator IFI35 to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 (PubMed:10779520, PubMed:10950963). In complex with IFI35, inhibits virus-triggered type I IFN-beta production when ubiquitinated by ubiquitin-protein ligase TRIM21 (PubMed:26342464). In complex with IFI35, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881). Negatively regulates virus-triggered type I interferon/IFN production by inducing proteosome-dependent degradation of IRF7, a transcriptional regulator of type I IFN, thereby interfering with cellular antiviral responses (By similarity). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation, when actively released by macrophage to the extracellular space during cell injury or pathogen invasion (PubMed:29038465). Macrophage-secreted NMI activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 binding and activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (PubMed:29038465)