Signaling lymphocytic activation molecule (CDw150) (IPO-3) (SLAM family member 1) (CD antigen CD150)
1_MDPKG 6_ LLSLT 11_ FVLFL 16_ SLAFG 21_ ASYGT 26_ GGRMM 31_ NCPKI 36_ LRQLG 41_ SKVLL 46_ PLTYE 51_ RINKS 56_ MNKSI 61_ HIVVT 66_ MAKSL 71_ ENSVE 76_ NKIVS 81_ LDPSE 86_ AGPPR 91_ YLGDR 96_ YKFYL 101_ ENLTL 106_ GIRES 111_ RKEDE 116_ GWYLM 121_ TLEKN 126_ VSVQR 131_ FCLQL 136_ RLYEQ 141_ VSTPE 146_ IKVLN 151_ KTQEN 156_ GTCTL 161_ ILGCT 166_ VEKGD 171_ HVAYS 176_ WSEKA 181_ GTHPL 186_ NPANS 191_ SHLLS 196_ LTLGP 201_ QHADN 206_ IYICT 211_ VSNPI 216_ SNNSQ 221_ TFSPW 226_ PGCRT 231_ DPSET 236_ KPWAV 241_ YAGLL 246_ GGVIM 251_ ILIMV 256_ VILQL 261_ RRRGK 266_ TNHYQ 271_ TTVEK 276_ KSLTI 281_ YAQVQ 286_ KPGPL 291_ QKKLD 296_ SFPAQ 301_ DPCTT 306_ IYVAA 311_ TEPVP 316_ ESVQE 321_ TNSIT 326_VYASV
1: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, signaling is also regulated by SH2D1A which can simultaneously interact with and recruit FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Mediates IL-2-independent proliferation of activated T-cells during immune responses and induces IFN-gamma production (By similarity). Downstreaming signaling involves INPP5D, DOK1 and DOK2 leading to inhibited IFN-gamma production in T-cells, and PRKCQ, BCL10 and NFKB1 leading to increased T-cell activation and Th2 cytokine production (By similarity). Promotes T-cell receptor-induced IL-4 secretion by CD4(+) cells (By similarity). Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4(-)/CD8(-) T-cells (By similarity). Required for IL-4 production by germinal centers T follicular helper (T(Fh))cells (By similarity). May inhibit CD40-induced signal transduction in monocyte-derived dendritic cells (PubMed:16317102). May play a role in allergic responses and may regulate allergen-induced Th2 cytokine and Th1 cytokine secretion (By similarity). In conjunction with SLAMF6 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage. Involved in the peripheral differentiation of indifferent natural killer T (iNKT) cells toward a regulatory NKT2 type (By similarity). In macrophages involved in down-regulation of IL-12, TNF-alpha and nitric oxide in response to lipopolysaccharide (LPS) (By similarity). In B-cells activates the ERK signaling pathway independently of SH2D1A but implicating both, SYK and INPP5D, and activates Akt signaling dependent on SYK and SH2D1A (By similarity). In B-cells also activates p38 MAPK and JNK1 and JNK2 (PubMed:20231852). In conjunction with CD84/SLAMF5 and SLAMF6 may be a negative regulator of the humoral immune response (By similarity). Involved in innate immune response against Gram-negative bacteria in macrophages; probably recognizes OmpC and/or OmpF on the bacterial surface, regulates phagosome maturation and recruitment of the PI3K complex II (PI3KC3-C2) leading to accumulation of PdtIns(3)P and NOX2 activity in the phagosomes (PubMed:20818396)
2: (Microbial infection) Acts as a receptor for Measles virus; also including isoform 4