Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2) (hKvbeta2)
1_MYPES 6_ TTGSP 11_ ARLSL 16_ RQTGS 21_ PGMIY 26_ STRYG 31_ SPKRQ 36_ LQFYR 41_ NLGKS 46_ GLRVS 51_ CLGLG 56_ TWVTF 61_ GGQIT 66_ DEMAE 71_ QLMTL 76_ AYDNG 81_ INLFD 86_ TAEVY 91_ AAGKA 96_ EVVLG 101_ NIIKK 106_ KGWRR 111_ SSLVI 116_ TTKIF 121_ WGGKA 126_ ETERG 131_ LSRKH 136_ IIEGL 141_ KASLE 146_ RLQLE 151_ YVDVV 156_ FANRP 161_ DPNTP 166_ MEETV 171_ RAMTH 176_ VINQG 181_ MAMYW 186_ GTSRW 191_ SSMEI 196_ MEAYS 201_ VARQF 206_ NLTPP 211_ ICEQA 216_ EYHMF 221_ QREKV 226_ EVQLP 231_ ELFHK 236_ IGVGA 241_ MTWSP 246_ LACGI 251_ VSGKY 256_ DSGIP 261_ PYSRA 266_ SLKGY 271_ QWLKD 276_ KILSE 281_ EGRRQ 286_ QAKLK 291_ ELQAI 296_ AERLG 301_ CTLPQ 306_ LAIAW 311_ CLRNE 316_ GVSSV 321_ LLGAS 326_ NADQL 331_ MENIG 336_ AIQVL 341_ PKLSS 346_ SIIHE 351_ IDSIL 356_ GNKPY 361_SKKDY
1: Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:11825900, PubMed:7649300). The beta-2/KCNAB2 cytoplasmic subunit promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:11825900, PubMed:7649300). Promotes the inactivation of Kv1.4/KCNA4 and Kv1.5/KCNA5 alpha subunit-containing channels (PubMed:11825900, PubMed:7649300). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a wide range of aldehyde and ketone substrates (By similarity). Substrate specificity includes methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro, no physiological substrate identified yet) (By similarity). The binding of oxidized and reduced nucleotide alters Kv channel gating and may contribute to dynamic fine tuning of cell excitability (By similarity). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity)