S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2)
1_MHRKH 6_ LQEIP 11_ DLSSN 16_ VATSF 21_ TWGWD 26_ SSKTS 31_ ELLSG 36_ MGVSA 41_ LEKEE 46_ PDSEN 51_ IPQEL 56_ LSNLG 61_ HPESP 66_ PRKRL 71_ KSKGS 76_ DKDFV 81_ IVRRP 86_ KLNRE 91_ NFPGV 96_ SWDSL 101_ PDELL 106_ LGIFS 111_ CLCLP 116_ ELLKV 121_ SGVCK 126_ RWYRL 131_ ASDES 136_ LWQTL 141_ DLTGK 146_ NLHPD 151_ VTGRL 156_ LSQGV 161_ IAFRC 166_ PRSFM 171_ DQPLA 176_ EHFSP 181_ FRVQH 186_ MDLSN 191_ SVIEV 196_ STLHG 201_ ILSQC 206_ SKLQN 211_ LSLEG 216_ LRLSD 221_ PIVNT 226_ LAKNS 231_ NLVRL 236_ NLSGC 241_ SGFSE 246_ FALQT 251_ LLSSC 256_ SRLDE 261_ LNLSW 266_ CFDFT 271_ EKHVQ 276_ VAVAH 281_ VSETI 286_ TQLNL 291_ SGYRK 296_ NLQKS 301_ DLSTL 306_ VRRCP 311_ NLVHL 316_ DLSDS 321_ VMLKN 326_ DCFQE 331_ FFQLN 336_ YLQHL 341_ SLSRC 346_ YDIIP 351_ ETLLE 356_ LGEIP 361_ TLKTL 366_ QVFGI 371_ VPDGT 376_ LQLLK 381_ EALPH 386_ LQINC 391_ SHFTT 396_ IARPT 401_ IGNKK 406_ NQEIW 411_ GIKCR 416_LTLQK
1: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:9736735, PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22464731, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1 (By similarity). Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, NBN, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22464731, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:9736735, PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219). Following phosphorylation in response to DNA damage, mediates 'Lys-63'-linked ubiquitination of NBN, promoting ATM recruitment to DNA damage sites and DNA repair via homologous recombination (PubMed:22464731)
2: Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus