Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated)
1_MSLVL 6_ NDLLI 11_ CCRQL 16_ EHDRA 21_ TERKK 26_ EVEKF 31_ KRLIR 36_ DPETI 41_ KHLDR 46_ HSDSK 51_ QGKYL 56_ NWDAV 61_ FRFLQ 66_ KYIQK 71_ ETECL 76_ RIAKP 81_ NVSAS 86_ TQASR 91_ QKKMQ 96_ EISSL 101_ VKYFI 106_ KCANR 111_ RAPRL 116_ KCQEL 121_ LNYIM 126_ DTVKD 131_ SSNGA 136_ IYGAD 141_ CSNIL 146_ LKDIL 151_ SVRKY 156_ WCEIS 161_ QQQWL 166_ ELFSV 171_ YFRLY 176_ LKPSQ 181_ DVHRV 186_ LVARI 191_ IHAVT 196_ KGCCS 201_ QTDGL 206_ NSKFL 211_ DFFSK 216_ AIQCA 221_ RQEKS 226_ SSGLN 231_ HILAA 236_ LTIFL 241_ KTLAV 246_ NFRIR 251_ VCELG 256_ DEILP 261_ TLLYI 266_ WTQHR 271_ LNDSL 276_ KEVII 281_ ELFQL 286_ QIYIH 291_ HPKGA 296_ KTQEK 301_ GAYES 306_ TKWRS 311_ ILYNL 316_ YDLLV 321_ NEISH 326_ IGSRG 331_ KYSSG 336_ FRNIA 341_ VKENL 346_ IELMA 351_ DICHQ 356_ VFNED 361_ TRSLE 366_ ISQSY 371_ TTTQR 376_ ESSDY 381_ SVPCK 386_ RKKIE 391_ LGWEV 396_ IKDHL 401_ QKSQN 406_ DFDLV 411_ PWLQI 416_ ATQLI 421_ SKYPA 426_ SLPNC 431_ ELSPL 436_ LMILS 441_ QLLPQ 446_ QRHGE 451_ RTPYV 456_ LRCLT 461_ EVALC 466_ QDKRS 471_ NLESS 476_ QKSDL 481_ LKLWN 486_ KIWCI 491_ TFRGI 496_ SSEQI 501_ QAENF 506_ GLLGA 511_ IIQGS 516_ LVEVD 521_ REFWK 526_ LFTGS 531_ ACRPS 536_ CPAVC 541_ CLTLA 546_ LTTSI 551_ VPGTV 556_ KMGIE 561_ QNMCE 566_ VNRSF 571_ SLKES 576_ IMKWL 581_ LFYQL 586_ EGDLE 591_ NSTEV 596_ PPILH 601_ SNFPH 606_ LVLEK 611_ ILVSL 616_ TMKNC 621_ KAAMN 626_ FFQSV 631_ PECEH 636_ HQKDK 641_ EELSF 646_ SEVEE 651_ LFLQT 656_ TFDKM 661_ DFLTI 666_ VRECG 671_ IEKHQ 676_ SSIGF 681_ SVHQN 686_ LKESL 691_ DRCLL 696_ GLSEQ 701_ LLNNY 706_ SSEIT 711_ NSETL 716_ VRCSR 721_ LLVGV 726_ LGCYC 731_ YMGVI 736_ AEEEA 741_ YKSEL 746_ FQKAK 751_ SLMQC 756_ AGESI 761_ TLFKN 766_ KTNEE 771_ FRIGS 776_ LRNMM 781_ QLCTR 786_ CLSNC 791_ TKKSP 796_ NKIAS 801_ GFFLR 806_ LLTSK 811_ LMNDI 816_ ADICK 821_ SLASF 826_ IKKPF 831_ DRGEV 836_ ESMED 841_ DTNGN 846_ LMEVE 851_ DQSSM 856_ NLFND 861_ YPDSS 866_ VSDAN 871_ EPGES 876_ QSTIG 881_ AINPL 886_ AEEYL 891_ SKQDL 896_ LFLDM 901_ LKFLC 906_ LCVTT 911_ AQTNT 916_ VSFRA 921_ ADIRR 926_ KLLML 931_ IDSST 936_ LEPTK 941_ SLHLH 946_ MYLML 951_ LKELP 956_ GEEYP 961_ LPMED 966_ VLELL 971_ KPLSN 976_ VCSLY 981_ RRDQD 986_ VCKTI 991_ LNHVL 996_ HVVKN 1001_ LGQSN 1006_ MDSEN 1011_ TRDAQ 1016_ GQFLT 1021_ VIGAF 1026_ WHLTK 1031_ ERKYI 1036_ FSVRM 1041_ ALVNC 1046_ LKTLL 1051_ EADPY 1056_ SKWAI 1061_ LNVMG 1066_ KDFPV 1071_ NEVFT 1076_ QFLAD 1081_ NHHQV 1086_ RMLAA 1091_ ESINR 1096_ LFQDT 1101_ KGDSS 1106_ RLLKA 1111_ LPLKL 1116_ QQTAF 1121_ ENAYL 1126_ KAQEG 1131_ MREMS 1136_ HSAEN 1141_ PETLD 1146_ EIYNR 1151_ KSVLL 1156_ TLIAV 1161_ VLSCS 1166_ PICEK 1171_ QALFA 1176_ LCKSV 1181_ KENGL 1186_ EPHLV 1191_ KKVLE 1196_ KVSET 1201_ FGYRR 1206_ LEDFM 1211_ ASHLD 1216_ YLVLE 1221_ WLNLQ 1226_ DTEYN 1231_ LSSFP 1236_ FILLN 1241_ YTNIE 1246_ DFYRS 1251_ CYKVL 1256_ IPHLV 1261_ IRSHF 1266_ DEVKS 1271_ IANQI 1276_ QEDWK 1281_ SLLTD 1286_ CFPKI 1291_ LVNIL 1296_ PYFAY 1301_ EGTRD 1306_ SGMAQ 1311_ QRETA 1316_ TKVYD 1321_ MLKSE 1326_ NLLGK 1331_ QIDHL 1336_ FISNL 1341_ PEIVV 1346_ ELLMT 1351_ LHEPA 1356_ NSSAS 1361_ QSTDL 1366_ CDFSG 1371_ DLDPA 1376_ PNPPH 1381_ FPSHV 1386_ IKATF 1391_ AYISN 1396_ CHKTK 1401_ LKSIL 1406_ EILSK 1411_ SPDSY 1416_ QKILL 1421_ AICEQ 1426_ AAETN 1431_ NVYKK 1436_ HRILK 1441_ IYHLF 1446_ VSLLL 1451_ KDIKS 1456_ GLGGA 1461_ WAFVL 1466_ RDVIY 1471_ TLIHY 1476_ INQRP 1481_ SCIMD 1486_ VSLRS 1491_ FSLCC 1496_ DLLSQ 1501_ VCQTA 1506_ VTYCK 1511_ DALEN 1516_ HLHVI 1521_ VGTLI 1526_ PLVYE 1531_ QVEVQ 1536_ KQVLD 1541_ LLKYL 1546_ VIDNK 1551_ DNENL 1556_ YITIK 1561_ LLDPF 1566_ PDHVV 1571_ FKDLR 1576_ ITQQK 1581_ IKYSR 1586_ GPFSL 1591_ LEEIN 1596_ HFLSV 1601_ SVYDA 1606_ LPLTR 1611_ LEGLK 1616_ DLRRQ 1621_ LELHK 1626_ DQMVD 1631_ IMRAS 1636_ QDNPQ 1641_ DGIMV 1646_ KLVVN 1651_ LLQLS 1656_ KMAIN 1661_ HTGEK 1666_ EVLEA 1671_ VGSCL 1676_ GEVGP 1681_ IDFST 1686_ IAIQH 1691_ SKDAS 1696_ YTKAL 1701_ KLFED 1706_ KELQW 1711_ TFIML 1716_ TYLNN 1721_ TLVED 1726_ CVKVR 1731_ SAAVT 1736_ CLKNI 1741_ LATKT 1746_ GHSFW 1751_ EIYKM 1756_ TTDPM 1761_ LAYLQ 1766_ PFRTS 1771_ RKKFL 1776_ EVPRF 1781_ DKENP 1786_ FEGLD 1791_ DINLW 1796_ IPLSE 1801_ NHDIW 1806_ IKTLT 1811_ CAFLD 1816_ SGGTK 1821_ CEILQ 1826_ LLKPM 1831_ CEVKT 1836_ DFCQT 1841_ VLPYL 1846_ IHDIL 1851_ LQDTN 1856_ ESWRN 1861_ LLSTH 1866_ VQGFF 1871_ TSCLR 1876_ HFSQT 1881_ SRSTT 1886_ PANLD 1891_ SESEH 1896_ FFRCC 1901_ LDKKS 1906_ QRTML 1911_ AVVDY 1916_ MRRQK 1921_ RPSSG 1926_ TIFND 1931_ AFWLD 1936_ LNYLE 1941_ VAKVA 1946_ QSCAA 1951_ HFTAL 1956_ LYAEI 1961_ YADKK 1966_ SMDDQ 1971_ EKRSL 1976_ AFEEG 1981_ SQSTT 1986_ ISSLS 1991_ EKSKE 1996_ ETGIS 2001_ LQDLL 2006_ LEIYR 2011_ SIGEP 2016_ DSLYG 2021_ CGGGK 2026_ MLQPI 2031_ TRLRT 2036_ YEHEA 2041_ MWGKA 2046_ LVTYD 2051_ LETAI 2056_ PSSTR 2061_ QAGII 2066_ QALQN 2071_ LGLCH 2076_ ILSVY 2081_ LKGLD 2086_ YENKD 2091_ WCPEL 2096_ EELHY 2101_ QAAWR 2106_ NMQWD 2111_ HCTSV 2116_ SKEVE 2121_ GTSYH 2126_ ESLYN 2131_ ALQSL 2136_ RDREF 2141_ STFYE 2146_ SLKYA 2151_ RVKEV 2156_ EEMCK 2161_ RSLES 2166_ VYSLY 2171_ PTLSR 2176_ LQAIG 2181_ ELESI 2186_ GELFS 2191_ RSVTH 2196_ RQLSE 2201_ VYIKW 2206_ QKHSQ 2211_ LLKDS 2216_ DFSFQ 2221_ EPIMA 2226_ LRTVI 2231_ LEILM 2236_ EKEMD 2241_ NSQRE 2246_ CIKDI 2251_ LTKHL 2256_ VELSI 2261_ LARTF 2266_ KNTQL 2271_ PERAI 2276_ FQIKQ 2281_ YNSVS 2286_ CGVSE 2291_ WQLEE 2296_ AQVFW 2301_ AKKEQ 2306_ SLALS 2311_ ILKQM 2316_ IKKLD 2321_ ASCAA 2326_ NNPSL 2331_ KLTYT 2336_ ECLRV 2341_ CGNWL 2346_ AETCL 2351_ ENPAV 2356_ IMQTY 2361_ LEKAV 2366_ EVAGN 2371_ YDGES 2376_ SDELR 2381_ NGKMK 2386_ AFLSL 2391_ ARFSD 2396_ TQYQR 2401_ IENYM 2406_ KSSEF 2411_ ENKQA 2416_ LLKRA 2421_ KEEVG 2426_ LLREH 2431_ KIQTN 2436_ RYTVK 2441_ VQREL 2446_ ELDEL 2451_ ALRAL 2456_ KEDRK 2461_ RFLCK 2466_ AVENY 2471_ INCLL 2476_ SGEEH 2481_ DMWVF 2486_ RLCSL 2491_ WLENS 2496_ GVSEV 2501_ NGMMK 2506_ RDGMK 2511_ IPTYK 2516_ FLPLM 2521_ YQLAA 2526_ RMGTK 2531_ MMGGL 2536_ GFHEV 2541_ LNNLI 2546_ SRISM 2551_ DHPHH 2556_ TLFII 2561_ LALAN 2566_ ANRDE 2571_ FLTKP 2576_ EVARR 2581_ SRITK 2586_ NVPKQ 2591_ SSQLD 2596_ EDRTE 2601_ AANRI 2606_ ICTIR 2611_ SRRPQ 2616_ MVRSV 2621_ EALCD 2626_ AYIIL 2631_ ANLDA 2636_ TQWKT 2641_ QRKGI 2646_ NIPAD 2651_ QPITK 2656_ LKNLE 2661_ DVVVP 2666_ TMEIK 2671_ VDHTG 2676_ EYGNL 2681_ VTIQS 2686_ FKAEF 2691_ RLAGG 2696_ VNLPK 2701_ IIDCV 2706_ GSDGK 2711_ ERRQL 2716_ VKGRD 2721_ DLRQD 2726_ AVMQQ 2731_ VFQMC 2736_ NTLLQ 2741_ RNTET 2746_ RKRKL 2751_ TICTY 2756_ KVVPL 2761_ SQRSG 2766_ VLEWC 2771_ TGTVP 2776_ IGEFL 2781_ VNNED 2786_ GAHKR 2791_ YRPND 2796_ FSAFQ 2801_ CQKKM 2806_ MEVQK 2811_ KSFEE 2816_ KYEVF 2821_ MDVCQ 2826_ NFQPV 2831_ FRYFC 2836_ MEKFL 2841_ DPAIW 2846_ FEKRL 2851_ AYTRS 2856_ VATSS 2861_ IVGYI 2866_ LGLGD 2871_ RHVQN 2876_ ILINE 2881_ QSAEL 2886_ VHIDL 2891_ GVAFE 2896_ QGKIL 2901_ PTPET 2906_ VPFRL 2911_ TRDIV 2916_ DGMGI 2921_ TGVEG 2926_ VFRRC 2931_ CEKTM 2936_ EVMRN 2941_ SQETL 2946_ LTIVE 2951_ VLLYD 2956_ PLFDW 2961_ TMNPL 2966_ KALYL 2971_ QQRPE 2976_ DETEL 2981_ HPTLN 2986_ ADDQE 2991_ CKRNL 2996_ SDIDQ 3001_ SFNKV 3006_ AERVL 3011_ MRLQE 3016_ KLKGV 3021_ EEGTV 3026_ LSVGG 3031_ QVNLL 3036_ IQQAI 3041_ DPKNL 3046_ SRLFP 3051_GWKAW
1: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15064416, PubMed:15448695, PubMed:15456891, PubMed:15790808, PubMed:15916964, PubMed:17923702, PubMed:21757780, PubMed:24534091, PubMed:35076389, PubMed:9733514). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15448695, PubMed:15456891, PubMed:15916964, PubMed:17923702, PubMed:24534091, PubMed:9733514). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:10550055, PubMed:10766245, PubMed:10802669, PubMed:10839545, PubMed:10910365, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:21757780, PubMed:24534091, PubMed:26240375, PubMed:26774286, PubMed:30171069, PubMed:30612738, PubMed:30886146, PubMed:30952868, PubMed:38128537, PubMed:9733515, PubMed:9843217). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566)