Dentin matrix acidic phosphoprotein 1 (DMP-1) (Dentin matrix protein 1)
1_MKISI 6_ LLMFL 11_ WGLSC 16_ ALPVT 21_ RYQNN 26_ ESEDS 31_ EEWKG 36_ HLAQA 41_ PTPPL 46_ ESSES 51_ SEGSK 56_ VSSEE 61_ QANED 66_ PSDST 71_ QSEEG 76_ LGSDD 81_ HQYIY 86_ RLAGG 91_ FSRST 96_ GKGGD 101_ DKDDD 106_ EDDSG 111_ DDTFG 116_ DDDSG 121_ PGPKD 126_ RQEGG 131_ NSRLG 136_ SDEDS 141_ DDTIQ 146_ ASEES 151_ APQGQ 156_ DSAQD 161_ TTSES 166_ RELDN 171_ EDRVD 176_ SKPEG 181_ GDSTQ 186_ ESESE 191_ EHWVG 196_ GGSDG 201_ ESSHG 206_ DGSEL 211_ DDEGM 216_ QSDDP 221_ ESIRS 226_ ERGNS 231_ RMNSA 236_ GMKSK 241_ ESGEN 246_ SEQAN 251_ TQDSG 256_ GSQLL 261_ EHPSR 266_ KIFRK 271_ SRISE 276_ EDDRS 281_ ELDDN 286_ NTMEE 291_ VKSDS 296_ TENSN 301_ SRDTG 306_ LSQPR 311_ RDSKG 316_ DSQED 321_ SKENL 326_ SQEES 331_ QNVDG 336_ PSSES 341_ SQEAN 346_ LSSQE 351_ NSSES 356_ QEEVV 361_ SESRG 366_ DNPDP 371_ TTSYV 376_ EDQED 381_ SDSSE 386_ EDSSH 391_ TLSHS 396_ KSESR 401_ EEQAD 406_ SESSE 411_ SLNFS 416_ EESPE 421_ SPEDE 426_ NSSSQ 431_ EGLQS 436_ HSSSA 441_ ESQSE 446_ ESHSE 451_ EDDSD 456_ SQDSS 461_ RSKED 466_ SNSTE 471_ SKSSS 476_ EEDGQ 481_ LKNIE 486_ IESRK 491_ LTVDA 496_ YHNKP 501_ IGDQD 506_DNDCQ
1: May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite