Corticotropin-releasing factor receptor 2 (CRF-R-2) (CRF-R2) (CRFR-2) (Corticotropin-releasing hormone receptor 2) (CRH-R-2) (CRH-R2)
1_MDAAL 6_ LHSLL 11_ EANCS 16_ LALAE 21_ ELLLD 26_ GWGPP 31_ LDPEG 36_ PYSYC 41_ NTTLD 46_ QIGTC 51_ WPRSA 56_ AGALV 61_ ERPCP 66_ EYFNG 71_ VKYNT 76_ TRNAY 81_ RECLE 86_ NGTWA 91_ SKINY 96_ SQCEP 101_ ILDDK 106_ QRKYD 111_ LHYRI 116_ ALVVN 121_ YLGHC 126_ VSVAA 131_ LVAAF 136_ LLFLA 141_ LRSIR 146_ CLRNV 151_ IHWNL 156_ ITTFI 161_ LRNVM 166_ WFLLQ 171_ LVDHE 176_ VHESN 181_ EVWCR 186_ CITTI 191_ FNYFV 196_ VTNFF 201_ WMFVE 206_ GCYLH 211_ TAIVM 216_ TYSTE 221_ RLRKC 226_ LFLFI 231_ GWCIP 236_ FPIIV 241_ AWAIG 246_ KLYYE 251_ NEQCW 256_ FGKEP 261_ GDLVD 266_ YIYQG 271_ PIILV 276_ LLINF 281_ VFLFN 286_ IVRIL 291_ MTKLR 296_ ASTTS 301_ ETIQY 306_ RKAVK 311_ ATLVL 316_ LPLLG 321_ ITYML 326_ FFVNP 331_ GEDDL 336_ SQIMF 341_ IYFNS 346_ FLQSF 351_ QGFFV 356_ SVFYC 361_ FFNGE 366_ VRSAV 371_ RKRWH 376_ RWQDH 381_ HSLRV 386_ PMARA 391_ MSIPT 396_ SPTRI 401_ SFHSI 406_KQTAA
1: G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels