Interferon-induced protein with tetratricopeptide repeats 5 (IFIT-5) (Interferon-induced 58 kDa protein) (Retinoic acid- and interferon-inducible 58 kDa protein) (P58)
1_MSEIR 6_ KDTLK 11_ AILLE 16_ LECHF 21_ TWNLL 26_ KEDID 31_ LFEVE 36_ DTIGQ 41_ QLEFL 46_ TTKSR 51_ LALYN 56_ LLAYV 61_ KHLKG 66_ QNKDA 71_ LECLE 76_ QAEEI 81_ IQQEH 86_ SDKEE 91_ VRSLV 96_ TWGNY 101_ AWVYY 106_ HMDQL 111_ EEAQK 116_ YTGKI 121_ GNVCK 126_ KLSSP 131_ SNYKL 136_ ECPET 141_ DCEKG 146_ WALLK 151_ FGGKY 156_ YQKAK 161_ AAFEK 166_ ALEVE 171_ PDNPE 176_ FNIGY 181_ AITVY 186_ RLDDS 191_ DREGS 196_ VKSFS 201_ LGPLR 206_ KAVTL 211_ NPDNS 216_ YIKVF 221_ LALKL 226_ QDVHA 231_ EAEGE 236_ KYIEE 241_ ILDQI 246_ SSQPY 251_ VLRYA 256_ AKFYR 261_ RKNSW 266_ NKALE 271_ LLKKA 276_ LEVTP 281_ TSSFL 286_ HHQMG 291_ LCYRA 296_ QMIQI 301_ KKATH 306_ NRPKG 311_ KDKLK 316_ VDELI 321_ SSAIF 326_ HFKAA 331_ MERDS 336_ MFAFA 341_ YTDLA 346_ NMYAE 351_ GGQYS 356_ NAEDI 361_ FRKAL 366_ RLENI 371_ TDDHK 376_ HQIHY 381_ HYGRF 386_ QEFHR 391_ KSENT 396_ AIHHY 401_ LEALK 406_ VKDRS 411_ PLRTK 416_ LTSAL 421_ KKLST 426_ KRLCH 431_ NALDV 436_ QSLSA 441_ LGFVY 446_ KLEGE 451_ KRQAA 456_ EYYEK 461_ AQKID 466_ PENAE 471_ FLTAL 476_CELRL
1: Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments (PubMed:23317505, PubMed:23774268, PubMed:25092312). Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner (PubMed:23334420). Also recognizes and selectively binds AT-rich dsDNA (PubMed:23774268). Additionally, as a mediator in innate immunity, positively regulates IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7 (PubMed:26334375)