Metastasis-associated protein MTA1
1_MAANM 6_ YRVGD 11_ YVYFE 16_ NSSSN 21_ PYLIR 26_ RIEEL 31_ NKTAN 36_ GNVEA 41_ KVVCF 46_ YRRRD 51_ ISSTL 56_ IALAD 61_ KHATL 66_ SVCYK 71_ AGPGA 76_ DNGEE 81_ GEIEE 86_ EMENP 91_ EMVDL 96_ PEKLK 101_ HQLRH 106_ RELFL 111_ SRQLE 116_ SLPAT 121_ HIRGK 126_ CSVTL 131_ LNETE 136_ SLKSY 141_ LERED 146_ FFFYS 151_ LVYDP 156_ QQKTL 161_ LADKG 166_ EIRVG 171_ NRYQA 176_ DITDL 181_ LKEGE 186_ EDGRD 191_ QSRLE 196_ TQVWE 201_ AHNPL 206_ TDKQI 211_ DQFLV 216_ VARSV 221_ GTFAR 226_ ALDCS 231_ SSVRQ 236_ PSLHM 241_ SAAAA 246_ SRDIT 251_ LFHAM 256_ DTLHK 261_ NIYDI 266_ SKAIS 271_ ALVPQ 276_ GGPVL 281_ CRDEM 286_ EEWSA 291_ SEANL 296_ FEEAL 301_ EKYGK 306_ DFTDI 311_ QQDFL 316_ PWKSL 321_ TSIIE 326_ YYYMW 331_ KTTDR 336_ YVQQK 341_ RLKAA 346_ EAESK 351_ LKQVY 356_ IPNYN 361_ KPNPN 366_ QISVN 371_ NVKAG 376_ VVNGT 381_ GAPGQ 386_ SPGAG 391_ RACES 396_ CYTTQ 401_ SYQWY 406_ SWGPP 411_ NMQCR 416_ LCASC 421_ WTYWK 426_ KYGGL 431_ KMPTR 436_ LDGER 441_ PGPNR 446_ SNMSP 451_ HGLPA 456_ RSSGS 461_ PKFAM 466_ KTRQA 471_ FYLHT 476_ TKLTR 481_ IARRL 486_ CREIL 491_ RPWHA 496_ ARHPY 501_ LPINS 506_ AAIKA 511_ ECTAR 516_ LPEAS 521_ QSPLV 526_ LKQAV 531_ RKPLE 536_ AVLRY 541_ LETHP 546_ RPPKP 551_ DPVKS 556_ VSSVL 561_ SSLTP 566_ AKVAP 571_ VINNG 576_ SPTIL 581_ GKRSY 586_ EQHNG 591_ VDGNM 596_ KKRLL 601_ MPSRG 606_ LANHG 611_ QARHM 616_ GPSRN 621_ LLLNG 626_ KSYPT 631_ KVRLI 636_ RGGSL 641_ PPVKR 646_ RRMNW 651_ IDAPD 656_ DVFYM 661_ ATEET 666_ RKIRK 671_ LLSSS 676_ ETKRA 681_ ARRPY 686_ KPIAL 691_ RQSQA 696_ LPPRP 701_ PPPAP 706_VNDEP
1: Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:17922032, PubMed:24413532). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (PubMed:16617102, PubMed:17671180, PubMed:21965678). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19837670). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity)
2: Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses