Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma)
1_MAPTW 6_ GPGMV 11_ SVVGP 16_ MGLLV 21_ VLLVG 26_ GCAAE 31_ EPPRF 36_ IKEPK 41_ DQIGV 46_ SGGVA 51_ SFVCQ 56_ ATGDP 61_ KPRVT 66_ WNKKG 71_ KKVNS 76_ QRFET 81_ IEFDE 86_ SAGAV 91_ LRIQP 96_ LRTPR 101_ DENVY 106_ ECVAQ 111_ NSVGE 116_ ITVHA 121_ KLTVL 126_ REDQL 131_ PSGFP 136_ NIDMG 141_ PQLKV 146_ VERTR 151_ TATML 156_ CAASG 161_ NPDPE 166_ ITWFK 171_ DFLPV 176_ DPSAS 181_ NGRIK 186_ QLRSE 191_ TFEST 196_ PIRGA 201_ LQIES 206_ SEETD 211_ QGKYE 216_ CVATN 221_ SAGVR 226_ YSSPA 231_ NLYVR 236_ ELREV 241_ RRVAP 246_ RFSIL 251_ PMSHE 256_ IMPGG 261_ NVNIT 266_ CVAVG 271_ SPMPY 276_ VKWMQ 281_ GAEDL 286_ TPEDD 291_ MPVGR 296_ NVLEL 301_ TDVKD 306_ SANYT 311_ CVAMS 316_ SLGVI 321_ EAVAQ 326_ ITVKS 331_ LPKAP 336_ GTPMV 341_ TENTA 346_ TSITI 351_ TWDSG 356_ NPDPV 361_ SYYVI 366_ EYKSK 371_ SQDGP 376_ YQIKE 381_ DITTT 386_ RYSIG 391_ GLSPN 396_ SEYEI 401_ WVSAV 406_ NSIGQ 411_ GPPSE 416_ SVVTR 421_ TGEQA 426_ PASAP 431_ RNVQA 436_ RMLSA 441_ TTMIV 446_ QWEEP 451_ VEPNG 456_ LIRGY 461_ RVYYT 466_ MEPEH 471_ PVGNW 476_ QKHNV 481_ DDSLL 486_ TTVGS 491_ LLEDE 496_ TYTVR 501_ VLAFT 506_ SVGDG 511_ PLSDP 516_ IQVKT 521_ QQGVP 526_ GQPMN 531_ LRAEA 536_ RSETS 541_ ITLSW 546_ SPPRQ 551_ ESIIK 556_ YELLF 561_ REGDH 566_ GREVG 571_ RTFDP 576_ TTSYV 581_ VEDLK 586_ PNTEY 591_ AFRLA 596_ ARSPQ 601_ GLGAF 606_ TPVVR 611_ QRTLQ 616_ SKPSA 621_ PPQDV 626_ KCVSV 631_ RSTAI 636_ LVSWR 641_ PPPPE 646_ THNGA 651_ LVGYS 656_ VRYRP 661_ LGSED 666_ PEPKE 671_ VNGIP 676_ PTTTQ 681_ ILLEA 686_ LEKWT 691_ QYRIT 696_ TVAHT 701_ EVGPG 706_ PESSP 711_ VVVRT 716_ DEDVP 721_ SAPPR 726_ KVEAE 731_ ALNAT 736_ AIRVL 741_ WRSPA 746_ PGRQH 751_ GQIRG 756_ YQVHY 761_ VRMEG 766_ AEARG 771_ PPRIK 776_ DVMLA 781_ DAQWE 786_ TDDTA 791_ EYEMV 796_ ITNLQ 801_ PETAY 806_ SITVA 811_ AYTMK 816_ GDGAR 821_ SKPKV 826_ VVTKG 831_ AVLGR 836_ PTLSV 841_ QQTPE 846_ GSLLA 851_ RWEPP 856_ AGTAE 861_ DQVLG 866_ YRLQF 871_ GREDS 876_ TPLAT 881_ LEFPP 886_ SEDRY 891_ TASGV 896_ HKGAT 901_ YVFRL 906_ AARSR 911_ GGLGE 916_ EAAEV 921_ LSIPE 926_ DTPRG 931_ HPQIL 936_ EAAGN 941_ ASAGT 946_ VLLRW 951_ LPPVP 956_ AERNG 961_ AIVKY 966_ TVAVR 971_ EAGAL 976_ GPARE 981_ TELPA 986_ AAEPG 991_ AENAL 996_ TLQGL 1001_ KPDTA 1006_ YDLQV 1011_ RAHTR 1016_ RGPGP 1021_ FSPPV 1026_ RYRTF 1031_ LRDQV 1036_ SPKNF 1041_ KVKMI 1046_ MKTSV 1051_ LLSWE 1056_ FPDNY 1061_ NSPTP 1066_ YKIQY 1071_ NGLTL 1076_ DVDGR 1081_ TTKKL 1086_ ITHLK 1091_ PHTFY 1096_ NFVLT 1101_ NRGSS 1106_ LGGLQ 1111_ QTVTA 1116_ WTAFN 1121_ LLNGK 1126_ PSVAP 1131_ KPDAD 1136_ GFIMV 1141_ YLPDG 1146_ QSPVP 1151_ VQSYF 1156_ IVMVP 1161_ LRKSR 1166_ GGQFL 1171_ TPLGS 1176_ PEDMD 1181_ LEELI 1186_ QDISR 1191_ LQRRS 1196_ LRHSR 1201_ QLEVP 1206_ RPYIA 1211_ ARFSV 1216_ LPPTF 1221_ HPGDQ 1226_ KQYGG 1231_ FDNRG 1236_ LEPGH 1241_ RYVLF 1246_ VLAVL 1251_ QKSEP 1256_ TFAAS 1261_ PFSDP 1266_ FQLDN 1271_ PDPQP 1276_ IVDGE 1281_ EGLIW 1286_ VIGPV 1291_ LAVVF 1296_ IICIV 1301_ IAILL 1306_ YKNKP 1311_ DSKRK 1316_ DSEPR 1321_ TKCLL 1326_ NNADL 1331_ APHHP 1336_ KDPVE 1341_ MRRIN 1346_ FQTPD 1351_ SGLRS 1356_ PLREP 1361_ GFHFE 1366_ SMLSH 1371_ PPIPI 1376_ ADMAE 1381_ HTERL 1386_ KANDS 1391_ LKLSQ 1396_ EYESI 1401_ DPGQQ 1406_ FTWEH 1411_ SNLEV 1416_ NKPKN 1421_ RYANV 1426_ IAYDH 1431_ SRVIL 1436_ QPIEG 1441_ IMGSD 1446_ YINAN 1451_ YVDGY 1456_ RCQNA 1461_ YIATQ 1466_ GPLPE 1471_ TFGDF 1476_ WRMVW 1481_ EQRSA 1486_ TIVMM 1491_ TRLEE 1496_ KSRIK 1501_ CDQYW 1506_ PNRGT 1511_ ETYGF 1516_ IQVTL 1521_ LDTIE 1526_ LATFC 1531_ VRTFS 1536_ LHKNG 1541_ SSEKR 1546_ EVRQF 1551_ QFTAW 1556_ PDHGV 1561_ PEYPT 1566_ PFLAF 1571_ LRRVK 1576_ TCNPP 1581_ DAGPI 1586_ VVHCS 1591_ AGVGR 1596_ TGCFI 1601_ VIDAM 1606_ LERIK 1611_ PEKTV 1616_ DVYGH 1621_ VTLMR 1626_ SQRNY 1631_ MVQTE 1636_ DQYSF 1641_ IHEAL 1646_ LEAVG 1651_ CGNTE 1656_ VPARS 1661_ LYAYI 1666_ QKLAQ 1671_ VEPGE 1676_ HVTGM 1681_ ELEFK 1686_ RLANS 1691_ KAHTS 1696_ RFISA 1701_ NLPCN 1706_ KFKNR 1711_ LVNIM 1716_ PYEST 1721_ RVCLQ 1726_ PIRGV 1731_ EGSDY 1736_ INASF 1741_ IDGYR 1746_ QQKAY 1751_ IATQG 1756_ PLAET 1761_ TEDFW 1766_ RMLWE 1771_ NNSTI 1776_ VVMLT 1781_ KLREM 1786_ GREKC 1791_ HQYWP 1796_ AERSA 1801_ RYQYF 1806_ VVDPM 1811_ AEYNM 1816_ PQYIL 1821_ REFKV 1826_ TDARD 1831_ GQSRT 1836_ VRQFQ 1841_ FTDWP 1846_ EQGVP 1851_ KSGEG 1856_ FIDFI 1861_ GQVHK 1866_ TKEQF 1871_ GQDGP 1876_ ISVHC 1881_ SAGVG 1886_ RTGVF 1891_ ITLSI 1896_ VLERM 1901_ RYEGV 1906_ VDIFQ 1911_ TVKML 1916_ RTQRP 1921_ AMVQT 1926_ EDEYQ 1931_ FCYQA 1936_ ALEYL 1941_GSFDH
1: Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed:21454754). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as a tyrosine phosphatase (PubMed:8524829). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (By similarity). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120)