Krueppel-like factor 1 (Erythroid krueppel-like transcription factor) (EKLF)
1_MATAE 6_ TALPS 11_ ISTLT 16_ ALGPF 21_ PDTQD 26_ DFLKW 31_ WRSEE 36_ AQDMG 41_ PGPPD 46_ PTEPP 51_ LHVKS 56_ EDQPG 61_ EEEDD 66_ ERGAD 71_ ATWDL 76_ DLLLT 81_ NFSGP 86_ EPGGA 91_ PQTCA 96_ LAPSE 101_ ASGAQ 106_ YPPPP 111_ ETLGA 116_ YAGGP 121_ GLVAG 126_ LLGSE 131_ DHSGW 136_ VRPAL 141_ RARAP 146_ DAFVG 151_ PALAP 156_ APAPE 161_ PKALA 166_ LQPVY 171_ PGPGA 176_ GSSGG 181_ YFPRT 186_ GLSVP 191_ AASGA 196_ PYGLL 201_ SGYPA 206_ MYPAP 211_ QYQGH 216_ FQLFR 221_ GLQGP 226_ APGPA 231_ TSPSF 236_ LSCLG 241_ PGTVG 246_ TGLGG 251_ TAEDP 256_ GVIAE 261_ TAPSK 266_ RGRRS 271_ WARKR 276_ QAAHT 281_ CAHPG 286_ CGKSY 291_ TKSSH 296_ LKAHL 301_ RTHTG 306_ EKPYA 311_ CTWEG 316_ CGWRF 321_ ARSDE 326_ LTRHY 331_ RKHTG 336_ QRPFR 341_ CQLCP 346_ RAFSR 351_ SDHLA 356_LHMKR
1: Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters (PubMed:21055716). When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation