Centromere protein R (CENP-R) (Beta-3-endonexin) (Integrin beta-3-binding protein) (Nuclear receptor-interacting factor 3)
1_MPVKR 6_ SLKLD 11_ GLLEE 16_ NSFDP 21_ SKITR 26_ KKSVI 31_ TYSPT 36_ TGTCQ 41_ MSLFA 46_ SPTSS 51_ EEQKH 56_ RNGLS 61_ NEKRK 66_ KLNHP 71_ SLTES 76_ KESTT 81_ KDNDE 86_ FMMLL 91_ SKVEK 96_ LSEEI 101_ MEIMQ 106_ NLSSI 111_ QALEG 116_ SRELE 121_ NLIGI 126_ SCASH 131_ FLKRE 136_ MQKTK 141_ ELMTK 146_ VNKQK 151_ LFEKS 156_ TGLPH 161_ KASRH 166_ LDSYE 171_FLKAI
1: Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex