RING-type E3 ubiquitin-protein ligase PPIL2 (EC 2.3.2.27) (CYC4) (Cyclophilin-60) (Cyclophilin-like protein Cyp-60) (Cyp60) (hCyP-60) (Probable inactive peptidyl-prolyl cis-trans isomerase-like 2) (PPIase) (Rotamase PPIL2)
1_MGKRQ 6_ HQKDK 11_ MYITC 16_ AEYTH 21_ FYGGK 26_ KPDLP 31_ QTNFR 36_ RLPFD 41_ HCSLS 46_ LQPFV 51_ YPVCT 56_ PDGIV 61_ FDLLN 66_ IVPWL 71_ KKYGT 76_ NPSNG 81_ EKLDG 86_ RSLIK 91_ LNFSK 96_ NSEGK 101_ YHCPV 106_ LFTVF 111_ TNNTH 116_ IVAVR 121_ TTGNV 126_ YAYEA 131_ VEQLN 136_ IKAKN 141_ FRDLL 146_ TDEPF 151_ SRQDI 156_ ITLQD 161_ PTNLD 166_ KFNVS 171_ NFYHV 176_ KNNMK 181_ IIDPD 186_ EEKAK 191_ QDPSY 196_ YLKNT 201_ NAETR 206_ ETLQE 211_ LYKEF 216_ KGDEI 221_ LAATM 226_ KAPEK 231_ KKVDK 236_ LNAAH 241_ YSTGK 246_ VSASF 251_ TSTAM 256_ VPETT 261_ HEAAA 266_ IDEDV 271_ LRYQF 276_ VKKKG 281_ YVRLH 286_ TNKGD 291_ LNLEL 296_ HCDLT 301_ PKTCE 306_ NFIRL 311_ CKKHY 316_ YDGTI 321_ FHRSI 326_ RNFVI 331_ QGGDP 336_ TGTGT 341_ GGESY 346_ WGKPF 351_ KDEFR 356_ PNLSH 361_ TGRGI 366_ LSMAN 371_ SGPNS 376_ NRSQF 381_ FITFR 386_ SCAYL 391_ DKKHT 396_ IFGRV 401_ VGGFD 406_ VLTAM 411_ ENVES 416_ DPKTD 421_ RPKEE 426_ IRIDA 431_ TTVFV 436_ DPYEE 441_ ADAQI 446_ AQERK 451_ TQLKV 456_ APETK 461_ VKSSQ 466_ PQAGS 471_ QGPQT 476_ FRQGV 481_ GKYIN 486_ PAATK 491_ RAAEE 496_ EPSTS 501_ ATVPM 506_ SKKKP 511_SRGFG
1: Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423). May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance (PubMed:15946952). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable)