Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Renal carcinoma antigen NY-REN-29)
1_MLTCN 6_ KAGSR 11_ MVVDA 16_ ANSNG 21_ PFQPV 26_ VLLHI 31_ RDVPP 36_ ADQEK 41_ LFIQK 46_ LRQCC 51_ VLFDF 56_ VSDPL 61_ SDLKW 66_ KEVKR 71_ AALSE 76_ MVEYI 81_ THNRN 86_ VITEP 91_ IYPEV 96_ VHMFA 101_ VNMFR 106_ TLPPS 111_ SNPTG 116_ AEFDP 121_ EEDEP 126_ TLEAA 131_ WPHLQ 136_ LVYEF 141_ FLRFL 146_ ESPDF 151_ QPNIA 156_ KKYID 161_ QKFVL 166_ QLLEL 171_ FDSED 176_ PRERD 181_ FLKTT 186_ LHRIY 191_ GKFLG 196_ LRAYI 201_ RKQIN 206_ NIFYR 211_ FIYET 216_ EHHNG 221_ IAELL 226_ EILGS 231_ IINGF 236_ ALPLK 241_ EEHKI 246_ FLLKV 251_ LLPLH 256_ KVKSL 261_ SVYHP 266_ QLAYC 271_ VVQFL 276_ EKDST 281_ LTEPV 286_ VMALL 291_ KYWPK 296_ THSPK 301_ EVMFL 306_ NELEE 311_ ILDVI 316_ EPSEF 321_ VKIME 326_ PLFRQ 331_ LAKCV 336_ SSPHF 341_ QVAER 346_ ALYYW 351_ NNEYI 356_ MSLIS 361_ DNAAK 366_ ILPIM 371_ FPSLY 376_ RNSKT 381_ HWNKT 386_ IHGLI 391_ YNALK 396_ LFMEM 401_ NQKLF 406_ DDCTQ 411_ QFKAE 416_ KLKEK 421_ LKMKE 426_ REEAW 431_ VKIEN 436_ LAKAN 441_ PQYTV 446_ YSQAS 451_ TMSIP 456_ VAMET 461_ DGPLF 466_ EDVQM 471_ LRKTV 476_ KDEAH 481_ QAQKD 486_ PKKDR 491_ PLARR 496_ KSELP 501_ QDPHT 506_ KKALE 511_ AHCRA 516_DELAS
1: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation