cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B)
1_MRRDE 6_ RDAKA 11_ MRSLQ 16_ PPDGA 21_ GSPPE 26_ SLRNG 31_ YVKSC 36_ VSPLR 41_ QDPPR 46_ GFFFH 51_ LCRFC 56_ NVELR 61_ PPPAS 66_ PQQPR 71_ RCSPF 76_ CRARL 81_ SLGAL 86_ AAFVL 91_ ALLLG 96_ AEPES 101_ WAAGA 106_ AWLRT 111_ LLSVC 116_ SHSLS 121_ PLFSI 126_ ACAFF 131_ FLTCF 136_ LTRTK 141_ RGPGP 146_ GRSCG 151_ SWWLL 156_ ALPAC 161_ CYLGD 166_ FLVWQ 171_ WWSWP 176_ WGDGD 181_ AGSAA 186_ PHTPP 191_ EAAAG 196_ RLLLV 201_ LSCVG 206_ LLLTL 211_ AHPLR 216_ LRHCV 221_ LVLLL 226_ ASFVW 231_ WVSFT 236_ SLGSL 241_ PSALR 246_ PLLSG 251_ LVGGA 256_ GCLLA 261_ LGLDH 266_ FFQIR 271_ EAPLH 276_ PRLSS 281_ AAEEK 286_ VPVIR 291_ PRRRS 296_ SCVSL 301_ GETAA 306_ SYYGS 311_ CKIFR 316_ RPSLP 321_ CISRE 326_ QMILW 331_ DWDLK 336_ QWYKP 341_ HYQNS 346_ GGGNG 351_ VDLSV 356_ LNEAR 361_ NMVSD 366_ LLTDP 371_ SLPPQ 376_ VISSL 381_ RSISS 386_ LMGAF 391_ SGSCR 396_ PKINP 401_ LTPFP 406_ GFYPC 411_ SEIED 416_ PAEKG 421_ DRKLN 426_ KGLNR 431_ NSLPT 436_ PQLRR 441_ SSGTS 446_ GLLPV 451_ EQSSR 456_ WDRNN 461_ GKRPH 466_ QEFGI 471_ SSQGC 476_ YLNGP 481_ FNSNL 486_ LTIPK 491_ QRSSS 496_ VSLTH 501_ HVGLR 506_ RAGVL 511_ SSLSP 516_ VNSSN 521_ HGPVS 526_ TGSLT 531_ NRSPI 536_ EFPDT 541_ ADFLN 546_ KPSVI 551_ LQRSL 556_ GNAPN 561_ TPDFY 566_ QQLRN 571_ SDSNL 576_ CNSCG 581_ HQMLK 586_ YVSTS 591_ ESDGT 596_ DCCSG 601_ KSGEE 606_ ENIFS 611_ KESFK 616_ LMETQ 621_ QEEET 626_ EKKDS 631_ RKLFQ 636_ EGDKW 641_ LTEEA 646_ QSEQQ 651_ TNIEQ 656_ EVSLD 661_ LILVE 666_ EYDSL 671_ IEKMS 676_ NWNFP 681_ IFELV 686_ EKMGE 691_ KSGRI 696_ LSQVM 701_ YTLFQ 706_ DTGLL 711_ EIFKI 716_ PTQQF 721_ MNYFR 726_ ALENG 731_ YRDIP 736_ YHNRI 741_ HATDV 746_ LHAVW 751_ YLTTR 756_ PVPGL 761_ QQIHN 766_ GCGTG 771_ NETDS 776_ DGRIN 781_ HGRIA 786_ YISSK 791_ SCSNP 796_ DESYG 801_ CLSSN 806_ IPALE 811_ LMALY 816_ VAAAM 821_ HDYDH 826_ PGRTN 831_ AFLVA 836_ TNAPQ 841_ AVLYN 846_ DRSVL 851_ ENHHA 856_ ASAWN 861_ LYLSR 866_ PEYNF 871_ LLHLD 876_ HVEFK 881_ RFRFL 886_ VIEAI 891_ LATDL 896_ KKHFD 901_ FLAEF 906_ NAKAN 911_ DVNSN 916_ GIEWS 921_ NENDR 926_ LLVCQ 931_ VCIKL 936_ ADING 941_ PAKVR 946_ DLHLK 951_ WTEGI 956_ VNEFY 961_ EQGDE 966_ EANLG 971_ LPISP 976_ FMDRS 981_ SPQLA 986_ KLQES 991_ FITHI 996_ VGPLC 1001_ NSYDA 1006_ AGLLP 1011_ GQWLE 1016_ AEEDN 1021_ DTESG 1026_ DDEDG 1031_ EELDT 1036_ EDEEM 1041_ ENNLN 1046_ PKPPR 1051_ RKSRR 1056_ RIFCQ 1061_ LMHHL 1066_ TENHK 1071_ IWKEI 1076_ VEEEE 1081_ KCKAD 1086_ GNKLQ 1091_ VENSS 1096_ LPQAD 1101_ EIQVI 1106_EEADE
1: Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (PubMed:21393242). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity)