Phosducin-like protein (PHLP)
1_MTTLD 6_ DKLLG 11_ EKLQY 16_ YYSSS 21_ EDEDS 26_ DHEDK 31_ DRGRC 36_ APASS 41_ SVPAE 46_ AELAG 51_ EGISV 56_ NTGPK 61_ GVIND 66_ WRRFK 71_ QLETE 76_ QREEQ 81_ CREME 86_ RLIKK 91_ LSMTC 96_ RSHLD 101_ EEEEQ 106_ QKQKD 111_ LQEKI 116_ SGKMT 121_ LKEFA 126_ IMNED 131_ QDDEE 136_ FLQQY 141_ RKQRM 146_ EEMRQ 151_ QLHKG 156_ PQFKQ 161_ VFEIS 166_ SGEGF 171_ LDMID 176_ KEQKS 181_ IVIMV 186_ HIYED 191_ GIPGT 196_ EAMNG 201_ CMICL 206_ AAEYP 211_ AVKFC 216_ KVKSS 221_ VIGAS 226_ SQFTR 231_ NALPA 236_ LLIYK 241_ GGELI 246_ GNFVR 251_ VTDQL 256_ GDDFF 261_ AVDLE 266_ AFLQE 271_ FGLLP 276_ EKEVL 281_ VLTSV 286_ RNSAT 291_ CHSED 296_SDLEI
1: Acts as a positive regulator of hedgehog signaling and regulates ciliary function
2: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers
3: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin