Probable methyltransferase TARBP1 (EC 2.1.1.-) (TAR RNA-binding protein 1) (TAR RNA-binding protein of 185 kDa) (TRP-185)
1_MEWVL 6_ AEALL 11_ SQSRD 16_ PRALL 21_ GALCQ 26_ GEASA 31_ ERVET 36_ LRFLL 41_ QRLED 46_ EEARG 51_ SGGAG 56_ ALPEA 61_ AREVA 66_ AGYLV 71_ PLLRS 76_ LRGRP 81_ AGGPD 86_ PSLQP 91_ RHRRR 96_ VLRAA 101_ GAALR 106_ SCVRL 111_ AGRPQ 116_ LAAAL 121_ AEEAL 126_ RDLLA 131_ GWRAP 136_ GAEAA 141_ VEVLA 146_ AVGPC 151_ LRPRE 156_ DGPLL 161_ ERVAG 166_ TAVAL 171_ ALGGG 176_ GDGDE 181_ AGPAE 186_ DAAAL 191_ VAGRL 196_ LPVLV 201_ QCGGA 206_ ALRAV 211_ WGGLA 216_ APGAS 221_ LGSGR 226_ VEEKL 231_ LVLSA 236_ LAEKL 241_ LPEPG 246_ GDRAR 251_ GAREA 256_ GPDAR 261_ RCWRF 266_ WRTVQ 271_ AGLGQ 276_ ADALT 281_ RKRAR 286_ YLLQR 291_ AVEVS 296_ AELGA 301_ DCTCG 306_ PQEGN 311_ GPSLF 316_ WWSER 321_ KKDEL 326_ LKFWE 331_ NYILI 336_ METLE 341_ GNQIH 346_ VIKPV 351_ LPKLN 356_ NLFEY 361_ AVSEE 366_ NGCWL 371_ FHPSW 376_ HMCIY 381_ KRMFE 386_ SENKI 391_ LSKEG 396_ VIHFL 401_ ELYET 406_ KILPF 411_ SPEFS 416_ EFIIG 421_ PLMDA 426_ LSESS 431_ LYSRS 436_ PGQPI 441_ GSCSP 446_ LGLKL 451_ QKFLV 456_ TYISL 461_ LPEEI 466_ KSSFL 471_ LKFIR 476_ KMTSR 481_ HWCAV 486_ PILFL 491_ SKALA 496_ NVPRH 501_ KALGI 506_ DGLLA 511_ LRDVI 516_ HCTMI 521_ THQIL 526_ LRGAA 531_ QCYLL 536_ QTAMN 541_ LLDVE 546_ KVSLS 551_ DVSTF 556_ LMSLR 561_ QEESL 566_ GRGTS 571_ LWTEL 576_ CDWLR 581_ VNESY 586_ FKPSP 591_ TCSSI 596_ GLHKT 601_ SLNAY 606_ VKSIV 611_ QEYVK 616_ SSAWE 621_ TGENC 626_ FMPDW 631_ FEAKL 636_ VSLMV 641_ LLAVD 646_ VEGMK 651_ TQYSG 656_ KQRTE 661_ NVLRI 666_ FLDPL 671_ LDVLM 676_ KFSTN 681_ AYMPL 686_ LKTDR 691_ CLQLL 696_ LKLLN 701_ TCRLK 706_ GSSAQ 711_ DDEVS 716_ TVLQN 721_ FFMST 726_ TESIS 731_ EFILR 736_ RLTMN 741_ ELNSV 746_ SDLDR 751_ CHLYL 756_ MVLTE 761_ LINLH 766_ LKVGW 771_ KRGNP 776_ IWRVI 781_ SLLKN 786_ ASIQH 791_ LQEMD 796_ SGQEP 801_ TVGSQ 806_ IQRVV 811_ SMAAL 816_ AMVCE 821_ AIDQK 826_ PELQL 831_ DSLHA 836_ GPLES 841_ FLSSL 846_ QLNQT 851_ LQKPH 856_ AEEQS 861_ SYAHP 866_ LECSS 871_ VLEES 876_ SSSQG 881_ WGKIV 886_ AQYIH 891_ DQWVC 896_ LSFLL 901_ KKYHT 906_ LIPTT 911_ GSEIL 916_ EPFLP 921_ AVQMP 926_ IRTLQ 931_ SALEA 936_ LTVLS 941_ SDQVL 946_ PVFHC 951_ LKVLV 956_ PKLLT 961_ SSESL 966_ CIESF 971_ DMAWK 976_ IISSL 981_ SNTQL 986_ IFWAN 991_ LKAFV 996_ QFVFD 1001_ NKVLT 1006_ IAAKI 1011_ KGQAY 1016_ FKIKE 1021_ IMYKI 1026_ IEMSA 1031_ IKTGV 1036_ FNTLI 1041_ SYCCQ 1046_ SWIVS 1051_ ASNVS 1056_ QGSLS 1061_ SAKNY 1066_ SELIL 1071_ EACIF 1076_ GTVFR 1081_ RDQRL 1086_ VQDVQ 1091_ TFIEN 1096_ LGHDC 1101_ AANIV 1106_ MENTK 1111_ REDHY 1116_ VRICA 1121_ VKFLC 1126_ LLDGS 1131_ NMSHK 1136_ LFIED 1141_ LAIKL 1146_ LDKDE 1151_ LVSKS 1156_ KKRYY 1161_ VNSLQ 1166_ HRVKN 1171_ RVWQT 1176_ LLVLF 1181_ PRLDQ 1186_ NFLNG 1191_ IIDRI 1196_ FQAGF 1201_ TNNQA 1206_ SIKYF 1211_ IEWII 1216_ ILILH 1221_ KFPQF 1226_ LPKFW 1231_ DCFSY 1236_ GEENL 1241_ KTSIC 1246_ TFLAV 1251_ LSHLD 1256_ IITQN 1261_ IPEKK 1266_ LILKQ 1271_ ALIVV 1276_ LQWCF 1281_ NHNFS 1286_ VRLYA 1291_ LVALK 1296_ KLWTV 1301_ CKVLS 1306_ VEEFD 1311_ ALTPV 1316_ IESSL 1321_ HQVES 1326_ MHGAG 1331_ NAKKN 1336_ WQRIQ 1341_ EHFFF 1346_ ATFHP 1351_ LKDYC 1356_ LETIF 1361_ YILPR 1366_ LSGLI 1371_ EDEWI 1376_ TIDKF 1381_ TRFTD 1386_ VPLAA 1391_ GFQWY 1396_ LSQTQ 1401_ LSKLK 1406_ PGDWS 1411_ QQDIG 1416_ TNLVE 1421_ ADNQA 1426_ EWTDV 1431_ QKKII 1436_ PWNSR 1441_ VSDLD 1446_ LELLF 1451_ QDRAA 1456_ RLGKS 1461_ ISRLI 1466_ VVASL 1471_ IDKPT 1476_ NLGGL 1481_ CRTCE 1486_ VFGAS 1491_ VLVVG 1496_ SLQCI 1501_ SDKQF 1506_ QHLSV 1511_ SAEQW 1516_ LPLVE 1521_ VKPPQ 1526_ LIDYL 1531_ QQKKT 1536_ EGYTI 1541_ IGVEQ 1546_ TAKSL 1551_ DLTQY 1556_ CFPEK 1561_ SLLLL 1566_ GNERE 1571_ GIPAN 1576_ LIQQL 1581_ DVCVE 1586_ IPQQG 1591_ IIRSL 1596_ NVHVS 1601_ GALLI 1606_ WEYTR 1611_ QQLLS 1616_HGDTK
1: S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in a subset of tRNA (PubMed:18412263, PubMed:31019095, PubMed:38867004). Selectively mediates Gm18 methylation of tRNAGln-TTG/CTG and tRNASer-TGA/GCT. Gm18 modification can enhance the stability of modified tRNAs (PubMed:38867004)
2: (Microbial infection) In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II (PubMed:7638159, PubMed:8626763, PubMed:8846792). Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA (PubMed:7638159, PubMed:8626763, PubMed:8846792)