Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2)
1_MSDKS 6_ ELKAE 11_ LERKK 16_ QRLAQ 21_ IREEK 26_ KRKEE 31_ ERKKK 36_ ETDQK 41_ KEAVA 46_ PVQEE 51_ SDLEK 56_ KRREA 61_ EALLQ 66_ SMGLT 71_ PESPI 76_ VFSEY 81_ WVPPP 86_ MSPSS 91_ KSVST 96_ PSEAG 101_ SQDSG 106_ DGAVG 111_ SRTLH 116_ WDTDP 121_ SVLQL 126_ HSDSD 131_ LGRGP 136_ IKLGM 141_ AKITQ 146_ VDFPP 151_ REIVT 156_ YTKET 161_ QTPVM 166_ AQPKE 171_ DEEED 176_ DDVVA 181_ PKPPI 186_ EPEEE 191_ KTLKK 196_ DEEND 201_ SKAPP 206_ HELTE 211_ EEKQQ 216_ ILHSE 221_ EFLSF 226_ FDHST 231_ RIVER 236_ ALSEQ 241_ INIFF 246_ DYSGR 251_ DLEDK 256_ EGEIQ 261_ AGAKL 266_ SLNRQ 271_ FFDER 276_ WSKHR 281_ VVSCL 286_ DWSSQ 291_ YPELL 296_ VASYN 301_ NNEDA 306_ PHEPD 311_ GVALV 316_ WNMKY 321_ KKTTP 326_ EYVFH 331_ CQSAV 336_ MSATF 341_ AKFHP 346_ NLVVG 351_ GTYSG 356_ QIVLW 361_ DNRSN 366_ KRTPV 371_ QRTPL 376_ SAAAH 381_ THPVY 386_ CVNVV 391_ GTQNA 396_ HNLIS 401_ ISTDG 406_ KICSW 411_ SLDML 416_ SHPQD 421_ SMELV 426_ HKQSK 431_ AVAVT 436_ SMSFP 441_ VGDVN 446_ NFVVG 451_ SEEGS 456_ VYTAC 461_ RHGSK 466_ AGISE 471_ MFEGH 476_ QGPIT 481_ GIHCH 486_ AAVGA 491_ VDFSH 496_ LFVTS 501_ SFDWT 506_ VKLWT 511_ TKNNK 516_ PLYSF 521_ EDNAD 526_ YVYDV 531_ MWSPT 536_ HPALF 541_ ACVDG 546_ MGRLD 551_ LWNLN 556_ NDTEV 561_ PTASI 566_ SVEGN 571_ PALNR 576_ VRWTH 581_ SGREI 586_ AVGDS 591_ EGQIV 596_ IYDVG 601_ EQIAV 606_ PRNDE 611_ WARFG 616_ RTLAE 621_ INANR 626_ ADAEE 631_EAATR
1: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:31079899). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:31079899). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (By similarity). Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity)