Origin recognition complex subunit 2
1_MSKPE 6_ LKEDK 11_ MLEVH 16_ FVGDD 21_ DVLNH 26_ ILDRE 31_ GGAKL 36_ KKERA 41_ QLLVN 46_ PKKII 51_ KKPEY 56_ DLEED 61_ DQEVL 66_ KDQNY 71_ VEIMG 76_ RDVQE 81_ SLKNG 86_ SATGG 91_ GNKVY 96_ SFQNR 101_ KHSEK 106_ MAKLA 111_ SELAK 116_ TPQKS 121_ VSFSL 126_ KNDPE 131_ ITINV 136_ PQSSK 141_ GHSAS 146_ DKVQP 151_ KNNDK 156_ SEFLS 161_ TAPRS 166_ LRKRL 171_ IVPRS 176_ HSDSE 181_ SEYSA 186_ SNSED 191_ DEGVA 196_ QEHEE 201_ DTNAV 206_ IFSQK 211_ IQAQN 216_ RVVSA 221_ PVGKE 226_ TPSKR 231_ MKRDK 236_ TSDLV 241_ EEYFE 246_ AHSSS 251_ KVLTS 256_ DRTLQ 261_ KLKRA 266_ KLDQQ 271_ TLRNL 276_ LSKVS 281_ PSFSA 286_ ELKQL 291_ NQQYE 296_ KLFHK 301_ WMLQL 306_ HLGFN 311_ IVLYG 316_ LGSKR 321_ DLLER 326_ FRTTM 331_ LQDSI 336_ HVVIN 341_ GFFPG 346_ ISVKS 351_ VLNSI 356_ TEEVL 361_ DHMGT 366_ FRSIL 371_ DQLDW 376_ IVNKF 381_ KEDSS 386_ LELFL 391_ LIHNL 396_ DSQML 401_ RGEKS 406_ QQIIG 411_ QLSSL 416_ HNIYL 421_ IASID 426_ HLNAP 431_ LMWDH 436_ AKQSL 441_ FNWLW 446_ YETTT 451_ YSPYT 456_ EETSY 461_ ENSLL 466_ VKQSG 471_ SLPLS 476_ SLTHV 481_ LRSLT 486_ PNARG 491_ IFRLL 496_ IKYQL 501_ DNQDN 506_ PSYIG 511_ LSFQD 516_ FYQQC 521_ REAFL 526_ VNSDL 531_ TLRAQ 536_ LTEFR 541_ DHKLI 546_ RTKKG 551_ TDGVE 556_ YLLIP 561_ VDNGT 566_ LTDFL 571_EKEEE
1: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3