Integrin-linked protein kinase (EC 2.7.11.1) (59 kDa serine/threonine-protein kinase) (Beta-integrin-linked kinase) (ILK-1) (ILK-2) (p59ILK)
1_MDDIF 6_ TQCRE 11_ GNAVA 16_ VRLWL 21_ DNTEN 26_ DLNQG 31_ DDHGF 36_ SPLHW 41_ ACREG 46_ RSAVV 51_ EMLIM 56_ RGARI 61_ NVMNR 66_ GDDTP 71_ LHLAA 76_ SHGHR 81_ DIVQK 86_ LLQYK 91_ ADINA 96_ VNEHG 101_ NVPLH 106_ YACFW 111_ GQDQV 116_ AEDLV 121_ ANGAL 126_ VSICN 131_ KYGEM 136_ PVDKA 141_ KAPLR 146_ ELLRE 151_ RAEKM 156_ GQNLN 161_ RIPYK 166_ DTFWK 171_ GTTRT 176_ RPRNG 181_ TLNKH 186_ SGIDF 191_ KQLNF 196_ LTKLN 201_ ENHSG 206_ ELWKG 211_ RWQGN 216_ DIVVK 221_ VLKVR 226_ DWSTR 231_ KSRDF 236_ NEECP 241_ RLRIF 246_ SHPNV 251_ LPVLG 256_ ACQSP 261_ PAPHP 266_ TLITH 271_ WMPYG 276_ SLYNV 281_ LHEGT 286_ NFVVD 291_ QSQAV 296_ KFALD 301_ MARGM 306_ AFLHT 311_ LEPLI 316_ PRHAL 321_ NSRSV 326_ MIDED 331_ MTARI 336_ SMADV 341_ KFSFQ 346_ CPGRM 351_ YAPAW 356_ VAPEA 361_ LQKKP 366_ EDTNR 371_ RSADM 376_ WSFAV 381_ LLWEL 386_ VTREV 391_ PFADL 396_ SNMEI 401_ GMKVA 406_ LEGLR 411_ PTIPP 416_ GISPH 421_ VCKLM 426_ KICMN 431_ EDPAK 436_ RPKFD 441_ MIVPI 446_LEKMQ
1: Scaffold protein which mediates protein-protein interactions during a range of cellular events including focal adhesion assembly, cell adhesion and cell migration (PubMed:17420447, PubMed:20005845, PubMed:30367047, PubMed:32528174). Regulates integrin-mediated signal transduction by contributing to inside-out integrin activation (By similarity). Recruits PARVA and LIMS1/PITCH to form the heterotrimeric IPP (ILK-PINCH-PARVIN) complex which binds to F-actin via the C-terminal tail of LIMS1 and the N-terminal region of PARVA, promoting F-actin filament bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (PubMed:30367047). Binding to PARVA promotes effective assembly of ILK into focal adhesions while PARVA-bound ILK can simultaneously engage integrin-beta cytoplasmic tails to mediate cell adhesion (PubMed:20005845). Plays a role with PARVG in promoting the cell adhesion and spreading of leukocytes (PubMed:16517730). Acts as an upstream effector of both AKT1/PKB and GSK3 (PubMed:9736715). Mediates trafficking of caveolae to the cell surface in an ITGB1-dependent manner by promoting the recruitment of IQGAP1 to the cell cortex which cooperates with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Required for the maintenance of mitotic spindle integrity by promoting phosphorylation of TACC3 by AURKA (PubMed:18283114). Associates with chromatin and may act as a negative regulator of transcription when located in the nucleus (PubMed:17420447)