DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1)
1_MDADE 6_ GQDMS 11_ QVSGK 16_ ESPPV 21_ SDTPD 26_ EGDEP 31_ MPIPE 36_ DLSTT 41_ SGGQQ 46_ SSKSD 51_ RVVAS 56_ NVKVE 61_ TQSDE 66_ ENGRA 71_ CEMNG 76_ EECAE 81_ DLRML 86_ DASGE 91_ KMNGS 96_ HRDQG 101_ SSALS 106_ GVGGI 111_ RLPNG 116_ KLKCD 121_ ICGII 126_ CIGPN 131_ VLMVH 136_ KRSHT 141_ GERPF 146_ QCNQC 151_ GASFT 156_ QKGNL 161_ LRHIK 166_ LHSGE 171_ KPFKC 176_ HLCNY 181_ ACRRR 186_ DALTG 191_ HLRTH 196_ SVGKP 201_ HKCGY 206_ CGRSY 211_ KQRSS 216_ LEEHK 221_ ERCHN 226_ YLESM 231_ GLPGT 236_ LYPVI 241_ KEETN 246_ HSEMA 251_ EDLCK 256_ IGSER 261_ SLVLD 266_ RLASN 271_ VAKRK 276_ SSMPQ 281_ KFLGD 286_ KGLSD 291_ TPYDS 296_ SASYE 301_ KENEM 306_ MKSHV 311_ MDQAI 316_ NNAIN 321_ YLGAE 326_ SLRPL 331_ VQTPP 336_ GGSEV 341_ VPVIS 346_ PMYQL 351_ HKPLA 356_ EGTPR 361_ SNHSA 366_ QDSAV 371_ ENLLL 376_ LSKAK 381_ LVPSE 386_ REASP 391_ SNSCQ 396_ DSTDT 401_ ESNNE 406_ EQRSG 411_ LIYLT 416_ NHIAP 421_ HARNG 426_ LSLKE 431_ EHRAY 436_ DLLRA 441_ ASENS 446_ QDALR 451_ VVSTS 456_ GEQMK 461_ VYKCE 466_ HCRVL 471_ FLDHV 476_ MYTIH 481_ MGCHG 486_ FRDPF 491_ ECNMC 496_ GYHSQ 501_ DRYEF 506_ SSHIT 511_RGEHR
1: Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067)