Zinc transporter ZIP6 (Estrogen-regulated protein LIV-1) (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6)
1_MARKL 6_ SVILI 11_ LTFAL 16_ SVTNP 21_ LHELK 26_ AAAFP 31_ QTTEK 36_ ISPNW 41_ ESGIN 46_ VDLAI 51_ STRQY 56_ HLQQL 61_ FYRYG 66_ ENNSL 71_ SVEGF 76_ RKLLQ 81_ NIGID 86_ KIKRI 91_ HIHHD 96_ HDHHS 101_ DHEHH 106_ SDHER 111_ HSDHE 116_ HHSEH 121_ EHHSD 126_ HDHHS 131_ HHNHA 136_ ASGKN 141_ KRKAL 146_ CPDHD 151_ SDSSG 156_ KDPRN 161_ SQGKG 166_ AHRPE 171_ HASGR 176_ RNVKD 181_ SVSAS 186_ EVTST 191_ VYNTV 196_ SEGTH 201_ FLETI 206_ ETPRP 211_ GKLFP 216_ KDVSS 221_ STPPS 226_ VTSKS 231_ RVSRL 236_ AGRKT 241_ NESVS 246_ EPRKG 251_ FMYSR 256_ NTNEN 261_ PQECF 266_ NASKL 271_ LTSHG 276_ MGIQV 281_ PLNAT 286_ EFNYL 291_ CPAII 296_ NQIDA 301_ RSCLI 306_ HTSEK 311_ KAEIP 316_ PKTYS 321_ LQIAW 326_ VGGFI 331_ AISII 336_ SFLSL 341_ LGVIL 346_ VPLMN 351_ RVFFK 356_ FLLSF 361_ LVALA 366_ VGTLS 371_ GDAFL 376_ HLLPH 381_ SHASH 386_ HHSHS 391_ HEEPA 396_ MEMKR 401_ GPLFS 406_ HLSSQ 411_ NIEES 416_ AYFDS 421_ TWKGL 426_ TALGG 431_ LYFMF 436_ LVEHV 441_ LTLIK 446_ QFKDK 451_ KKKNQ 456_ KKPEN 461_ DDDVE 466_ IKKQL 471_ SKYES 476_ QLSTN 481_ EEKVD 486_ TDDRT 491_ EGYLR 496_ ADSQE 501_ PSHFD 506_ SQQPA 511_ VLEEE 516_ EVMIA 521_ HAHPQ 526_ EVYNE 531_ YVPRG 536_ CKNKC 541_ HSHFH 546_ DTLGQ 551_ SDDLI 556_ HHHHD 561_ YHHIL 566_ HHHHH 571_ QNHHP 576_ HSHSQ 581_ RYSRE 586_ ELKDA 591_ GVATL 596_ AWMVI 601_ MGDGL 606_ HNFSD 611_ GLAIG 616_ AAFTE 621_ GLSSG 626_ LSTSV 631_ AVFCH 636_ ELPHE 641_ LGDFA 646_ VLLKA 651_ GMTVK 656_ QAVLY 661_ NALSA 666_ MLAYL 671_ GMATG 676_ IFIGH 681_ YAENV 686_ SMWIF 691_ ALTAG 696_ LFMYV 701_ ALVDM 706_ VPEML 711_ HNDAS 716_ DHGCS 721_ RWGYF 726_ FLQNA 731_ GMLLG 736_ FGIML 741_ LISIF 746_EHKIV
1: Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT) (PubMed:12839489, PubMed:18272141, PubMed:21422171, PubMed:23919497, PubMed:27274087, PubMed:34394081). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT) (PubMed:27274087). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT (By similarity). Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence (PubMed:23919497). In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes (PubMed:21422171, PubMed:30552163, PubMed:34394081). Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition (PubMed:25143461)