Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145)
1_MATEH 6_ PEPPK 11_ AELQL 16_ PPPPP 21_ PGHYG 26_ AWAAQ 31_ ELQAK 36_ LAEIG 41_ APIQG 46_ NREEL 51_ VERLQ 56_ SYTRQ 61_ TGIVL 66_ NRPVL 71_ RGEDG 76_ DKAAP 81_ PPMSA 86_ QLPGI 91_ PMPPP 96_ PLGLP 101_ PLQPP 106_ PPPPP 111_ PPPGL 116_ GLGFP 121_ MAHPP 126_ NLGPP 131_ PPLRV 136_ GEPVA 141_ LSEEE 146_ RLKLA 151_ QQQAA 156_ LLMQQ 161_ EERAK 166_ QQGDH 171_ SLKEH 176_ ELLEQ 181_ QKRAA 186_ VLLEQ 191_ ERQQE 196_ IAKMG 201_ TPVPR 206_ PPQDM 211_ GQIGV 216_ RTPLG 221_ PRVAA 226_ PVGPV 231_ GPTPT 236_ VLPMG 241_ APVPR 246_ PRGPP 251_ PPPGD 256_ ENREM 261_ DDPSV 266_ GPKIP 271_ QALEK 276_ ILQLK 281_ ESRQE 286_ EMNSQ 291_ QEEEE 296_ METDA 301_ RSSLG 306_ QSASE 311_ TEEDT 316_ VSVSK 321_ KEKNR 326_ KRRNR 331_ KKKKK 336_ PQRVR 341_ GVSSE 346_ SSGDR 351_ EKDST 356_ RSRGS 361_ DSPAA 366_ DVEIE 371_ YVTEE 376_ PEIYE 381_ PNFIF 386_ FKRIF 391_ EAFKL 396_ TDDVK 401_ KEKEK 406_ EPEKL 411_ DKLEN 416_ SAAPK 421_ KKGFE 426_ EEHKD 431_ SDDDS 436_ SDDEQ 441_ EKKPE 446_ APKLS 451_ KKKLR 456_ RMNRF 461_ TVAEL 466_ KQLVA 471_ RPDVV 476_ EMHDV 481_ TAQDP 486_ KLLVH 491_ LKATR 496_ NSVPV 501_ PRHWC 506_ FKRKY 511_ LQGKR 516_ GIEKP 521_ PFELP 526_ DFIKR 531_ TGIQE 536_ MREAL 541_ QEKEE 546_ QKTMK 551_ SKMRE 556_ KVRPK 561_ MGKID 566_ IDYQK 571_ LHDAF 576_ FKWQT 581_ KPKLT 586_ IHGDL 591_ YYEGK 596_ EFETR 601_ LKEKK 606_ PGDLS 611_ DELRI 616_ SLGMP 621_ VGPNA 626_ HKVPP 631_ PWLIA 636_ MQRYG 641_ PPPSY 646_ PNLKI 651_ PGLNS 656_ PIPES 661_ CSFGY 666_ HAGGW 671_ GKPPV 676_ DETGK 681_ PLYGD 686_ VFGTN 691_ AAEFQ 696_ TKTEE 701_ EEIDR 706_ TPWGE 711_ LEPSD 716_ EESSE 721_ EEEEE 726_ ESDED 731_ KPDET 736_ GFITP 741_ ADSGL 746_ ITPGG 751_ FSSVP 756_ AGMET 761_ PELIE 766_ LRKKK 771_ IEEAM 776_ DGSET 781_ PQLFT 786_ VLPEK 791_ RTATV 796_ GGAMM 801_ GSTHI 806_ YDMST 811_ VMSRK 816_ GPAPE 821_ LQGVE 826_ VALAP 831_ EELEL 836_ DPMAM 841_ TQKYE 846_ EHVRE 851_ QQAQV 856_ EKEDF 861_ SDMVA 866_ EHAAK 871_ QKQKK 876_ RKAQP 881_ QDSRG 886_GSKKY
1: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932)