Protein OS-9 (Amplified in osteosarcoma 9)
1_MAAET 6_ LLSSL 11_ LGLLL 16_ LGLLL 21_ PASLT 26_ GGVGS 31_ LNLEE 36_ LSEMR 41_ YGIEI 46_ LPLPV 51_ MGGQS 56_ QSSDV 61_ VIVSS 66_ KYKQR 71_ YECRL 76_ PAGAI 81_ HFQRE 86_ REEET 91_ PAYQG 96_ PGIPE 101_ LLSPM 106_ RDAPC 111_ LLKTK 116_ DWWTY 121_ EFCYG 126_ RHIQQ 131_ YHMED 136_ SEIKG 141_ EVLYL 146_ GYYQS 151_ AFDWD 156_ DETAK 161_ ASKQH 166_ RLKRY 171_ HSQTY 176_ GNGSK 181_ CDLNG 186_ RPREA 191_ EVRFL 196_ CDEGA 201_ GISGD 206_ YIDRV 211_ DEPLS 216_ CSYVL 221_ TIRTP 226_ RLCPH 231_ PLLRP 236_ PPSAA 241_ PQAIL 246_ CHPSL 251_ QPEEY 256_ MAYVQ 261_ RQADS 266_ KQYGD 271_ KIIEE 276_ LQDLG 281_ PQVWS 286_ ETKSG 291_ VAPQK 296_ MAGAS 301_ PTKDD 306_ SKDSD 311_ FWKML 316_ NEPED 321_ QAPGG 326_ EEVPA 331_ EEQDP 336_ SPEAA 341_ DSASG 346_ APNDF 351_ QNNVQ 356_ VKVIR 361_ SPADL 366_ IRFIE 371_ ELKGG 376_ TKKGK 381_ PNIGQ 386_ EQPVD 391_ DAAEV 396_ PQREP 401_ EKERG 406_ DPERQ 411_ REMEE 416_ EEDED 421_ EDEDE 426_ DEDER 431_ QLLGE 436_ FEKEL 441_ EGILL 446_ PSDRD 451_ RLRSE 456_ VKAGM 461_ ERELE 466_ NIIQE 471_ TEKEL 476_ DPDGL 481_ KKESE 486_ RDRAM 491_ LALTS 496_ TLNKL 501_ IKRLE 506_ EKQSP 511_ ELVKK 516_ HKKKR 521_ VVPKK 526_ PPPSP 531_ QPTEE 536_ DPEHR 541_ VRVRV 546_ TKLRL 551_ GGPNQ 556_ DLTVL 561_ EMKRE 566_ NPQLK 571_ QIEGL 576_ VKELL 581_ EREGL 586_ TAAGK 591_ IEIKI 596_ VRPWA 601_ EGTEE 606_ GARWL 611_ TDEDT 616_ RNLKE 621_ IFFNI 626_ LVPGA 631_ EEAQK 636_ ERQRQ 641_ KELES 646_ NYRRV 651_ WGSPG 656_ GEGTG 661_DLDEF
1: Lectin component of the HRD1 complex, which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD) (PubMed:18264092, PubMed:18417469, PubMed:19084021, PubMed:19346256, PubMed:21172656, PubMed:24899641). Specifically recognizes and binds improperly folded glycoproteins as well as hyperglycosylated proteins, retain them in the ER, and transfers them to the ubiquitination machinery and promote their degradation (PubMed:18264092, PubMed:18417469, PubMed:19084021, PubMed:19346256, PubMed:21172656, PubMed:24899641). Possible targets include TRPV4 as well as hyperglycosylated HSP90B1 (PubMed:17932042)