Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin)
1_MRLAL 6_ LWALG 11_ LLGAG 16_ SPLPS 21_ WPLPN 26_ IGGTE 31_ EQQAE 36_ SEKAP 41_ REPLE 46_ PQVLQ 51_ DDLPI 56_ SLKKV 61_ LQTSL 66_ PEPLR 71_ IKLEL 76_ DGDSH 81_ ILELL 86_ QNREL 91_ VPGRP 96_ TLVWY 101_ QPDGT 106_ RVVSE 111_ GHTLE 116_ NCCYQ 121_ GRVRG 126_ YAGSW 131_ VSICT 136_ CSGLR 141_ GLVVL 146_ TPERS 151_ YTLEQ 156_ GPGDL 161_ QGPPI 166_ ISRIQ 171_ DLHLP 176_ GHTCA 181_ LSWRE 186_ SVHTQ 191_ KPPEH 196_ PLGQR 201_ HIRRR 206_ RDVVT 211_ ETKTV 216_ ELVIV 221_ ADHSE 226_ AQKYR 231_ DFQHL 236_ LNRTL 241_ EVALL 246_ LDTFF 251_ RPLNV 256_ RVALV 261_ GLEAW 266_ TQRDL 271_ VEISP 276_ NPAVT 281_ LENFL 286_ HWRRA 291_ HLLPR 296_ LPHDS 301_ AQLVT 306_ GTSFS 311_ GPTVG 316_ MAIQN 321_ SICSP 326_ DFSGG 331_ VNMDH 336_ STSIL 341_ GVASS 346_ IAHEL 351_ GHSLG 356_ LDHDL 361_ PGNSC 366_ PCPGP 371_ APAKT 376_ CIMEA 381_ STDFL 386_ PGLNF 391_ SNCSR 396_ RALEK 401_ ALLDG 406_ MGSCL 411_ FERLP 416_ SLPPM 421_ AAFCG 426_ NMFVE 431_ PGEQC 436_ DCGFL 441_ DDCVD 446_ PCCDS 451_ LTCQL 456_ RPGAQ 461_ CASDG 466_ PCCQN 471_ CQLRP 476_ SGWQC 481_ RPTRG 486_ DCDLP 491_ EFCPG 496_ DSSQC 501_ PPDVS 506_ LGDGE 511_ PCAGG 516_ QAVCM 521_ HGRCA 526_ SYAQQ 531_ CQSLW 536_ GPGAQ 541_ PAAPL 546_ CLQTA 551_ NTRGN 556_ AFGSC 561_ GRNPS 566_ GSYVS 571_ CTPRD 576_ AICGQ 581_ LQCQT 586_ GRTQP 591_ LLGSI 596_ RDLLW 601_ ETIDV 606_ NGTEL 611_ NCSWV 616_ HLDLG 621_ SDVAQ 626_ PLLTL 631_ PGTAC 636_ GPGLV 641_ CIDHR 646_ CQRVD 651_ LLGAQ 656_ ECRSK 661_ CHGHG 666_ VCDSN 671_ RHCYC 676_ EEGWA 681_ PPDCT 686_ TQLKA 691_ TSSLT 696_ TGLLL 701_ SLLVL 706_ LVLVM 711_ LGASY 716_ WYRAR 721_ LHQRL 726_ CQLKG 731_ PTCQY 736_ RAAQS 741_ GPSER 746_ PGPPQ 751_ RALLA 756_ RGTKQ 761_ ASALS 766_ FPAPP 771_ SRPLP 776_ PDPVS 781_ KRLQA 786_ ELADR 791_ PNPPT 796_ RPLPA 801_ DPVVR 806_ SPKSQ 811_ GPAKP 816_ PPPRK 821_ PLPAD 826_ PQGRC 831_ PSGDL 836_ PGPGA 841_ GIPPL 846_ VVPSR 851_ PAPPP 856_PTVSS
1: Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain