Transmembrane emp24 domain-containing protein 1 (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor-binding protein) (p24 family protein gamma-1) (Tp24) (p24gamma1)
1_MMAAG 6_ AALAL 11_ ALWLL 16_ MPPVE 21_ VGGAG 26_ PPPIQ 31_ DGEFT 36_ FLLPA 41_ GRKQC 46_ FYQSA 51_ PANAS 56_ LETEY 61_ QVIGG 66_ AGLDV 71_ DFTLE 76_ SPQGV 81_ LLVSE 86_ SRKAD 91_ GVHTV 96_ EPTEA 101_ GDYKL 106_ CFDNS 111_ FSTIS 116_ EKLVF 121_ FELIF 126_ DSLQD 131_ DEEVE 136_ GWAEA 141_ VEPEE 146_ MLDVK 151_ MEDIK 156_ ESIET 161_ MRTRL 166_ ERSIQ 171_ MLTLL 176_ RAFEA 181_ RDRNL 186_ QEGNL 191_ ERVNF 196_ WSAVN 201_ VAVLL 206_ LVAVL 211_ QVCTL 216_ KRFFQ 221_DKRPV
1: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6 production by interacting with interleukin-33 receptor IL1RL1 (PubMed:23319592). Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325)