Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
1_MTTDE 6_ GAKNN 11_ EESPT 16_ ATVAE 21_ QGEDI 26_ TSKKD 31_ RGVLK 36_ IVKRV 41_ GNGEE 46_ TPMIG 51_ DKVYV 56_ HYKGK 61_ LSNGK 66_ KFDSS 71_ HDRNE 76_ PFVFS 81_ LGKGQ 86_ VIKAW 91_ DIGVA 96_ TMKKG 101_ EICHL 106_ LCKPE 111_ YAYGS 116_ AGSLP 121_ KIPSN 126_ ATLFF 131_ EIELL 136_ DFKGE 141_ DLFED 146_ GGIIR 151_ RTKRK 156_ GEGYS 161_ NPNEG 166_ ATVEI 171_ HLEGR 176_ CGGRM 181_ FDCRD 186_ VAFTV 191_ GEGED 196_ HDIPI 201_ GIDKA 206_ LEKMQ 211_ REEQC 216_ ILYLG 221_ PRYGF 226_ GEAGK 231_ PKFGI 236_ EPNAE 241_ LIYEV 246_ TLKSF 251_ EKAKE 256_ SWEMD 261_ TKEKL 266_ EQAAI 271_ VKEKG 276_ TVYFK 281_ GGKYM 286_ QAVIQ 291_ YGKIV 296_ SWLEM 301_ EYGLS 306_ EKESK 311_ ASESF 316_ LLAAF 321_ LNLAM 326_ CYLKL 331_ REYTK 336_ AVECC 341_ DKALG 346_ LDSAN 351_ EKGLY 356_ RRGEA 361_ QLLMN 366_ EFESA 371_ KGDFE 376_ KVLEV 381_ NPQNK 386_ AARLQ 391_ ISMCQ 396_ KKAKE 401_ HNERD 406_ RRIYA 411_ NMFKK 416_ FAEQD 421_ AKEEA 426_ NKAMG 431_ KKTSE 436_ GVTNE 441_ KGTDS 446_ QAMEE 451_EKPEG
1: Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277, PubMed:28363942). Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappa-B activation, and IFN production (PubMed:26101251, PubMed:31434731)