Tumor suppressor candidate 3 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3) (Oligosaccharyl transferase subunit TUSC3) (Magnesium uptake/transporter TUSC3) (Protein N33)
1_MGARG 6_ APSRR 11_ RQAGR 16_ RLRYL 21_ PTGSF 26_ PFLLL 31_ LLLLC 36_ IQLGG 41_ GQKKK 46_ ENLLA 51_ EKVEQ 56_ LMEWS 61_ SRRSI 66_ FRMNG 71_ DKFRK 76_ FIKAP 81_ PRNYS 86_ MIVMF 91_ TALQP 96_ QRQCS 101_ VCRQA 106_ NEEYQ 111_ ILANS 116_ WRYSS 121_ AFCNK 126_ LFFSM 131_ VDYDE 136_ GTDVF 141_ QQLNM 146_ NSAPT 151_ FMHFP 156_ PKGRP 161_ KRADT 166_ FDLQR 171_ IGFAA 176_ EQLAK 181_ WIADR 186_ TDVHI 191_ RVFRP 196_ PNYSG 201_ TIALA 206_ LLVSL 211_ VGGLL 216_ YLRRN 221_ NLEFI 226_ YNKTG 231_ WAMVS 236_ LCIVF 241_ AMTSG 246_ QMWNH 251_ IRGPP 256_ YAHKN 261_ PHNGQ 266_ VSYIH 271_ GSSQA 276_ QFVAE 281_ SHIIL 286_ VLNAA 291_ ITMGM 296_ VLLNE 301_ AATSK 306_ GDVGK 311_ RRIIC 316_ LVGLG 321_ LVVFF 326_ FSFLL 331_ SIFRS 336_ KYHGY 341_PYSDL
1: Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Also has oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. Could indirectly play a role in Mg(2+) transport (PubMed:19717468)