Unconventional myosin-IXb (Unconventional myosin-9b)
1_MSVKE 6_ AGSSG 11_ RREQA 16_ AYHLH 21_ IYPQL 26_ STTES 31_ QASCR 36_ VTATK 41_ DSTTS 46_ DVIKD 51_ AIASL 56_ RLDGT 61_ KCYVL 66_ VEVKE 71_ SGGEE 76_ WVLDA 81_ NDSPV 86_ HRVLL 91_ WPRRA 96_ QDEHP 101_ QEDGY 106_ YFLLQ 111_ ERNAD 116_ GTIKY 121_ VHMQL 126_ VAQAT 131_ ATRRL 136_ VERGL 141_ LPRQQ 146_ ADFDD 151_ LCNLP 156_ ELTEG 161_ NLLKN 166_ LKHRF 171_ LQQKI 176_ YTYAG 181_ SILVA 186_ INPFK 191_ FLPIY 196_ NPKYV 201_ KMYEN 206_ QQLGK 211_ LEPHV 216_ FALAD 221_ VAYYT 226_ MLRKR 231_ VNQCI 236_ VISGE 241_ SGSGK 246_ TQSTN 251_ FLIHC 256_ LTALS 261_ QKGYA 266_ SGVER 271_ TILGA 276_ GPVLE 281_ AFGNA 286_ KTAHN 291_ NNSSR 296_ FGKFI 301_ QVSYL 306_ ESGIV 311_ RGAVV 316_ EKYLL 321_ EKSRL 326_ VSQEK 331_ DERNY 336_ HVFYY 341_ LLLGV 346_ SEEER 351_ QEFQL 356_ KQPED 361_ YFYLN 366_ QHNLK 371_ IEDGE 376_ DLKHD 381_ FERLK 386_ QAMEM 391_ VGFLP 396_ ATKKQ 401_ IFAVL 406_ SAILY 411_ LGNVT 416_ YKKRA 421_ TGREE 426_ GLEVG 431_ PPEVL 436_ DTLSQ 441_ LLKVK 446_ REILV 451_ EVLTK 456_ RKTVT 461_ VNDKL 466_ ILPYS 471_ LSEAI 476_ TARDS 481_ MAKSL 486_ YSALF 491_ DWIVL 496_ RINHA 501_ LLNKK 506_ DVEEA 511_ VSCLS 516_ IGVLD 521_ IFGFE 526_ DFERN 531_ SFEQF 536_ CINYA 541_ NEQLQ 546_ YYFNQ 551_ HIFKL 556_ EQEEY 561_ QGEGI 566_ TWHNI 571_ GYTDN 576_ VGCIH 581_ LISKK 586_ PTGLF 591_ YLLDE 596_ ESNFP 601_ HATSQ 606_ TLLAK 611_ FKQQH 616_ EDNKY 621_ FLGTP 626_ VMEPA 631_ FIIQH 636_ FAGKV 641_ KYQIK 646_ DFREK 651_ NMDYM 656_ RPDIV 661_ ALLRG 666_ SDSSY 671_ VRELI 676_ GMDPV 681_ AVFRW 686_ AVLRA 691_ AIRAM 696_ AVLRE 701_ AGRLR 706_ AERAE 711_ KAAGM 716_ SSPGA 721_ QSHPE 726_ ELPRG 731_ ASTPS 736_ EKLYR 741_ DLHNQ 746_ MIKSI 751_ KGLPW 756_ QGEDP 761_ RSLLQ 766_ SLSRL 771_ QKPRA 776_ FILKS 781_ KGIKQ 786_ KQIIP 791_ KNLLD 796_ SKSLK 801_ LIISM 806_ TLHDR 811_ TTKSL 816_ LHLHK 821_ KKKPP 826_ SISAQ 831_ FQTSL 836_ NKLLE 841_ ALGKA 846_ EPFFI 851_ RCIRS 856_ NAEKK 861_ ELCFD 866_ DELVL 871_ QQLRY 876_ TGMLE 881_ TVRIR 886_ RSGYS 891_ AKYTF 896_ QDFTE 901_ QFQVL 906_ LPKDA 911_ QPCRE 916_ VISTL 921_ LEKMK 926_ IDKRN 931_ YQIGK 936_ TKVFL 941_ KETER 946_ QALQE 951_ TLHRE 956_ VVRKI 961_ LLLQS 966_ WFRMV 971_ LERRH 976_ FLQMK 981_ RAAVT 986_ IQACW 991_ RSYRV 996_ RRALE 1001_ RTQAA 1006_ VYLQA 1011_ SWRGY 1016_ WQRKL 1021_ YRHQK 1026_ QSIIR 1031_ LQSLC 1036_ RGHLQ 1041_ RKSFS 1046_ QMISE 1051_ KQKAE 1056_ EKERE 1061_ ALEAA 1066_ RAGAE 1071_ EGGQG 1076_ QAAGG 1081_ QQVAE 1086_ QGPEP 1091_ AEDGG 1096_ HLASE 1101_ PEVQP 1106_ SDRSP 1111_ LEHSS 1116_ PEKEA 1121_ PSPEK 1126_ TLPPQ 1131_ KTVAA 1136_ ESHEK 1141_ VPSSR 1146_ EKRES 1151_ RRQRG 1156_ LEHVK 1161_ FQNKH 1166_ IQSCK 1171_ EESAL 1176_ REPSR 1181_ RVTQE 1186_ QGVSL 1191_ LEDKK 1196_ ESRED 1201_ ETLLV 1206_ VETEA 1211_ ENTSQ 1216_ KQPTE 1221_ QPQAM 1226_ AVGKV 1231_ SEETE 1236_ KTLPS 1241_ GSPRP 1246_ GQLER 1251_ PTSLA 1256_ LDSRV 1261_ SPPAP 1266_ GSAPE 1271_ TPEDK 1276_ SKPCG 1281_ SPRVQ 1286_ EKPDS 1291_ PGGST 1296_ QIQRY 1301_ LDAER 1306_ LASAV 1311_ ELWRG 1316_ KKLVA 1321_ AASPS 1326_ AMLSQ 1331_ SLDLS 1336_ DRHRA 1341_ TGAAL 1346_ TPTEE 1351_ RRTSF 1356_ STSDV 1361_ SKLLP 1366_ SLAKA 1371_ QPAAE 1376_ TTDGE 1381_ RSAKK 1386_ PAVQK 1391_ KKPGD 1396_ ASSLP 1401_ DAGLS 1406_ PGSQV 1411_ DSKST 1416_ FKRLF 1421_ LHKTK 1426_ DKKYS 1431_ LEGAE 1436_ ELENA 1441_ VSGHV 1446_ VLEAT 1451_ TMKKG 1456_ LEAPS 1461_ GQQHR 1466_ HAAGE 1471_ KRTKE 1476_ PGGKG 1481_ KKNRN 1486_ VKIGK 1491_ ITVSE 1496_ KWRES 1501_ VFRQI 1506_ TNANE 1511_ LKYLD 1516_ EFLLN 1521_ KINDL 1526_ RSQKT 1531_ PIESL 1536_ FIEAT 1541_ EKFRS 1546_ NIKTM 1551_ YSVPN 1556_ GKIHV 1561_ GYKDL 1566_ MENYQ 1571_ IVVSN 1576_ LATER 1581_ GQKDT 1586_ NLVLN 1591_ LFQSL 1596_ LDEFT 1601_ RGYTK 1606_ NDFEP 1611_ VKQSK 1616_ AQKKK 1621_ RKQER 1626_ AVQEH 1631_ NGHVF 1636_ ASYQV 1641_ SIPQS 1646_ CEQCL 1651_ SYIWL 1656_ MDKAL 1661_ LCSVC 1666_ KMTCH 1671_ KKCVH 1676_ KIQSH 1681_ CSYTY 1686_ GRKGE 1691_ PGVEP 1696_ GHFGV 1701_ CVDSL 1706_ TSDKA 1711_ SVPIV 1716_ LEKLL 1721_ EHVEM 1726_ HGLYT 1731_ EGLYR 1736_ KSGAA 1741_ NRTRE 1746_ LRQAL 1751_ QTDPA 1756_ AVKLE 1761_ NFPIH 1766_ AITGV 1771_ LKQWL 1776_ RELPE 1781_ PLMTF 1786_ AQYGD 1791_ FLRAV 1796_ ELPEK 1801_ QEQLA 1806_ AIYAV 1811_ LEHLP 1816_ EANHN 1821_ SLERL 1826_ IFHLV 1831_ KVALL 1836_ EDVNR 1841_ MSPGA 1846_ LAIIF 1851_ APCLL 1856_ RCPDN 1861_ SDPLT 1866_ SMKDV 1871_ LKITT 1876_ CVEML 1881_ IKEQM 1886_ RKYKV 1891_ KMEEI 1896_ SQLEA 1901_ AESIA 1906_ FRRLS 1911_ LLRQN 1916_ APWPL 1921_ KLGFS 1926_ SPYEG 1931_ VLNKS 1936_ PKTRD 1941_ IQEEE 1946_ LEVLL 1951_ EEEAA 1956_ GGDED 1961_ REKEI 1966_ LIERI 1971_ QSIKE 1976_ EKEDI 1981_ TYRLP 1986_ ELDPR 1991_ GSDEE 1996_ NLDSE 2001_ TSAST 2006_ ESLLE 2011_ ERAGR 2016_ GASEG 2021_ PPAPA 2026_ LPCPG 2031_ APTPS 2036_ PLPTV 2041_ AAPPR 2046_ RRPSS 2051_ FVTVR 2056_ VKTPR 2061_ RTPIM 2066_ PTANI 2071_ KLPPG 2076_ LPSHL 2081_ PRWAP 2086_ GAREA 2091_ AAPVR 2096_ RREPP 2101_ ARRPD 2106_ QIHSV 2111_ YITPG 2116_ ADLPV 2121_ QGALE 2126_ PLEED 2131_ GQPPG 2136_ AKRRY 2141_ SDPPT 2146_ YCLPP 2151_ASGQT
1: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257)