Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK)
1_MSTGD 6_ SFETR 11_ FEKMD 16_ NLLRD 21_ PKSEV 26_ NSDCL 31_ LDGLD 36_ ALVYD 41_ LDFPA 46_ LRKNK 51_ NIDNF 56_ LSRYK 61_ DTINK 66_ IRDLR 71_ MKAED 76_ YEVVK 81_ VIGRG 86_ AFGEV 91_ QLVRH 96_ KSTRK 101_ VYAMK 106_ LLSKF 111_ EMIKR 116_ SDSAF 121_ FWEER 126_ DIMAF 131_ ANSPW 136_ VVQLF 141_ YAFQD 146_ DRYLY 151_ MVMEY 156_ MPGGD 161_ LVNLM 166_ SNYDV 171_ PEKWA 176_ RFYTA 181_ EVVLA 186_ LDAIH 191_ SMGFI 196_ HRDVK 201_ PDNML 206_ LDKSG 211_ HLKLA 216_ DFGTC 221_ MKMNK 226_ EGMVR 231_ CDTAV 236_ GTPDY 241_ ISPEV 246_ LKSQG 251_ GDGYY 256_ GRECD 261_ WWSVG 266_ VFLYE 271_ MLVGD 276_ TPFYA 281_ DSLVG 286_ TYSKI 291_ MNHKN 296_ SLTFP 301_ DDNDI 306_ SKEAK 311_ NLICA 316_ FLTDR 321_ EVRLG 326_ RNGVE 331_ EIKRH 336_ LFFKN 341_ DQWAW 346_ ETLRD 351_ TVAPV 356_ VPDLS 361_ SDIDT 366_ SNFDD 371_ LEEDK 376_ GEEET 381_ FPIPK 386_ AFVGN 391_ QLPFV 396_ GFTYY 401_ SNRRY 406_ LSSAN 411_ PNDNR 416_ TSSNA 421_ DKSLQ 426_ ESLQK 431_ TIYKL 436_ EEQLH 441_ NEMQL 446_ KDEME 451_ QKCRT 456_ SNIKL 461_ DKIMK 466_ ELDEE 471_ GNQRR 476_ NLEST 481_ VSQIE 486_ KEKML 491_ LQHRI 496_ NEYQR 501_ KAEQE 506_ NEKRR 511_ NVENE 516_ VSTLK 521_ DQLED 526_ LKKVS 531_ QNSQL 536_ ANEKL 541_ SQLQK 546_ QLEEA 551_ NDLLR 556_ TESDT 561_ AVRLR 566_ KSHTE 571_ MSKSI 576_ SQLES 581_ LNREL 586_ QERNR 591_ ILENS 596_ KSQTD 601_ KDYYQ 606_ LQAIL 611_ EAERR 616_ DRGHD 621_ SEMIG 626_ DLQAR 631_ ITSLQ 636_ EEVKH 641_ LKHNL 646_ EKVEG 651_ ERKEA 656_ QDMLN 661_ HSEKE 666_ KNNLE 671_ IDLNY 676_ KLKSL 681_ QQRLE 686_ QEVNE 691_ HKVTK 696_ ARLTD 701_ KHQSI 706_ EEAKS 711_ VAMCE 716_ MEKKL 721_ KEERE 726_ AREKA 731_ ENRVV 736_ QIEKQ 741_ CSMLD 746_ VDLKQ 751_ SQQKL 756_ EHLTG 761_ NKERM 766_ EDEVK 771_ NLTLQ 776_ LEQES 781_ NKRLL 786_ LQNEL 791_ KTQAF 796_ EADNL 801_ KGLEK 806_ QMKQE 811_ INTLL 816_ EAKRL 821_ LEFEL 826_ AQLTK 831_ QYRGN 836_ EGQMR 841_ ELQDQ 846_ LEAEQ 851_ YFSTL 856_ YKTQV 861_ KELKE 866_ EIEEK 871_ NRENL 876_ KKIQE 881_ LQNEK 886_ ETLAT 891_ QLDLA 896_ ETKAE 901_ SEQLA 906_ RGLLE 911_ EQYFE 916_ LTQES 921_ KKAAS 926_ RNRQE 931_ ITDKD 936_ HTVSR 941_ LEEAN 946_ SMLTK 951_ DIEIL 956_ RRENE 961_ ELTEK 966_ MKKAE 971_ EEYKL 976_ EKEEE 981_ ISNLK 986_ AAFEK 991_ NINTE 996_ RTLKT 1001_ QAVNK 1006_ LAEIM 1011_ NRKDF 1016_ KIDRK 1021_ KANTQ 1026_ DLRKK 1031_ EKENR 1036_ KLQLE 1041_ LNQER 1046_ EKFNQ 1051_ MVVKH 1056_ QKELN 1061_ DMQAQ 1066_ LVEEC 1071_ AHRNE 1076_ LQMQL 1081_ ASKES 1086_ DIEQL 1091_ RAKLL 1096_ DLSDS 1101_ TSVAS 1106_ FPSAD 1111_ ETDGN 1116_ LPESR 1121_ IEGWL 1126_ SVPNR 1131_ GNIKR 1136_ YGWKK 1141_ QYVVV 1146_ SSKKI 1151_ LFYND 1156_ EQDKE 1161_ QSNPS 1166_ MVLDI 1171_ DKLFH 1176_ VRPVT 1181_ QGDVY 1186_ RAETE 1191_ EIPKI 1196_ FQILY 1201_ ANEGE 1206_ CRKDV 1211_ EMEPV 1216_ QQAEK 1221_ TNFQN 1226_ HKGHE 1231_ FIPTL 1236_ YHFPA 1241_ NCDAC 1246_ AKPLW 1251_ HVFKP 1256_ PPALE 1261_ CRRCH 1266_ VKCHR 1271_ DHLDK 1276_ KEDLI 1281_ CPCKV 1286_ SYDVT 1291_ SARDM 1296_ LLLAC 1301_ SQDEQ 1306_ KKWVT 1311_ HLVKK 1316_ IPKNP 1321_ PSGFV 1326_ RASPR 1331_ TLSTR 1336_ STANQ 1341_ SFRKV 1346_VKNTS
1: Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity)