Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1)
1_MNAPE 6_ RQPQP 11_ DGGDA 16_ PGHEP 21_ GGSPQ 26_ DELDF 31_ SILFD 36_ YEYLN 41_ PNEEE 46_ PNAHK 51_ VASPP 56_ SGPAY 61_ PDDVL 66_ DYGLK 71_ PYSPL 76_ ASLSG 81_ EPPGR 86_ FGEPD 91_ RVGPQ 96_ KFLSA 101_ AKPAG 106_ ASGLS 111_ PRIEI 116_ TPSHE 121_ LIQAV 126_ GPLRM 131_ RDAGL 136_ LVEQP 141_ PLAGV 146_ AASPR 151_ FTLPV 156_ PGFEG 161_ YREPL 166_ CLSPA 171_ SSGSS 176_ ASFIS 181_ DTFSP 186_ YTSPC 191_ VSPNN 196_ GGPDD 201_ LCPQF 206_ QNIPA 211_ HYSPR 216_ TSPIM 221_ SPRTS 226_ LAEDS 231_ CLGRH 236_ SPVPR 241_ PASRS 246_ SSPGA 251_ KRRHS 256_ CAEAL 261_ VALPP 266_ GASPQ 271_ RSRSP 276_ SPQPS 281_ SHVAP 286_ QDHGS 291_ PAGYP 296_ PVAGS 301_ AVIMD 306_ ALNSL 311_ ATDSP 316_ CGIPP 321_ KMWKT 326_ SPDPS 331_ PVSAA 336_ PSKAG 341_ LPRHI 346_ YPAVE 351_ FLGPC 356_ EQGER 361_ RNSAP 366_ ESILL 371_ VPPTW 376_ PKPLV 381_ PAIPI 386_ CSIPV 391_ TASLP 396_ PLEWP 401_ LSSQS 406_ GSYEL 411_ RIEVQ 416_ PKPHH 421_ RAHYE 426_ TEGSR 431_ GAVKA 436_ PTGGH 441_ PVVQL 446_ HGYME 451_ NKPLG 456_ LQIFI 461_ GTADE 466_ RILKP 471_ HAFYQ 476_ VHRIT 481_ GKTVT 486_ TTSYE 491_ KIVGN 496_ TKVLE 501_ IPLEP 506_ KNNMR 511_ ATIDC 516_ AGILK 521_ LRNAD 526_ IELRK 531_ GETDI 536_ GRKNT 541_ RVRLV 546_ FRVHI 551_ PESSG 556_ RIVSL 561_ QTASN 566_ PIECS 571_ QRSAH 576_ ELPMV 581_ ERQDT 586_ DSCLV 591_ YGGQQ 596_ MILTG 601_ QNFTS 606_ ESKVV 611_ FTEKT 616_ TDGQQ 621_ IWEME 626_ ATVDK 631_ DKSQP 636_ NMLFV 641_ EIPEY 646_ RNKHI 651_ RTPVK 656_ VNFYV 661_ INGKR 666_ KRSQP 671_ QHFTY 676_ HPVPA 681_ IKTEP 686_ TDEYD 691_ PTLIC 696_ SPTHG 701_ GLGSQ 706_ PYYPQ 711_ HPMVA 716_ ESPSC 721_ LVATM 726_ APCQQ 731_ FRTGL 736_ SSPDA 741_ RYQQQ 746_ NPAAV 751_ LYQRS 756_ KSLSP 761_ SLLGY 766_ QQPAL 771_ MAAPL 776_ SLADA 781_ HRSVL 786_ VHAGS 791_ QGQSS 796_ ALLHP 801_ SPTNQ 806_ QASPV 811_ IHYSP 816_ TNQQL 821_ RCGSH 826_ QEFQH 831_ IMYCE 836_ NFAPG 841_ TTRPG 846_ PPPVS 851_ QGQRL 856_ SPGSY 861_ PTVIQ 866_ QQNAT 871_ SQRAA 876_ KNGPP 881_ VSDQK 886_ EVLPA 891_ GVTIK 896_ QEQNL 901_ DQTYL 906_ DDVNE 911_ IIRKE 916_FSGPP
1: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses