Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1)
1_MLPEA 6_ GSLWL 11_ LKLLR 16_ DIQLA 21_ QFYWP 26_ ILEEL 31_ NVTRP 36_ EHFDF 41_ VKPED 46_ LDGIG 51_ MGRPA 56_ QRRLS 61_ EALKR 66_ LRSGP 71_ KSKNW 76_ VYKIL 81_ GGFAP 86_ EHKEP 91_ TLPSD 96_ SPRHL 101_ PEPEG 106_ GLKCL 111_ IPEGA 116_ VCRGE 121_ LLGSG 126_ CFGVV 131_ HRGLW 136_ TLPSG 141_ KSVPV 146_ AVKSL 151_ RVGPE 156_ GPMGT 161_ ELGDF 166_ LREVS 171_ VMMNL 176_ EHPHV 181_ LRLHG 186_ LVLGQ 191_ PLQMV 196_ MELAP 201_ LGSLH 206_ ARLTA 211_ PAPTP 216_ PLLVA 221_ LLCLF 226_ LRQLA 231_ GAMAY 236_ LGARG 241_ LVHRD 246_ LATRN 251_ LLLAS 256_ PRTIK 261_ VADFG 266_ LVRPL 271_ GGARG 276_ RYVMG 281_ GPRPI 286_ PYAWC 291_ APESL 296_ RHGAF 301_ SSASD 306_ VWMFG 311_ VTLWE 316_ MFSGG 321_ EEPWA 326_ GVPPY 331_ LILQR 336_ LEDRA 341_ RLPRP 346_ PLCSR 351_ ALYSL 356_ ALRCW 361_ APHPA 366_ DRPSF 371_ SHLEG 376_ LLQEA 381_ GPSEA 386_ CCVRD 391_ VTEPG 396_ ALRME 401_ TGDPI 406_ TVIEG 411_ SSSFH 416_ SPDST 421_ IWKGQ 426_ NGRTF 431_ KVGSF 436_ PASAV 441_ TLADA 446_ GGLPA 451_ TRPVH 456_ RGTPA 461_ RGDQH 466_ PGSID 471_ GDRKK 476_ ANLWD 481_ APPAR 486_ GQRRN 491_ MPLER 496_ MKGIS 501_ RSLES 506_ VLSLG 511_ PRPTG 516_ GGSSP 521_ PEIRQ 526_ ARAVP 531_ QGPPG 536_ LPPRP 541_ PLSSS 546_ SPQPS 551_ QPSRE 556_ RLPWP 561_ KRKPP 566_ HNHPM 571_ GMPGA 576_ RKAAA 581_ LSGGL 586_ LSDPE 591_ LQRKI 596_ MEVEL 601_ SVHGV 606_ THQEC 611_ QTALG 616_ ATGGD 621_ VVSAI 626_ RNLKV 631_ DQLFH 636_ LSSRS 641_ RADCW 646_ RILEH 651_ YQWDL 656_ SAASR 661_YVLAR
1: Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction