Mucosal addressin cell adhesion molecule 1 (MAdCAM-1) (hMAdCAM-1)
1_MDFGL 6_ ALLLA 11_ GLLGL 16_ LLGQS 21_ LQVKP 26_ LQVEP 31_ PEPVV 36_ AVALG 41_ ASRQL 46_ TCRLA 51_ CADRG 56_ ASVQW 61_ RGLDT 66_ SLGAV 71_ QSDTG 76_ RSVLT 81_ VRNAS 86_ LSAAG 91_ TRVCV 96_ GSCGG 101_ RTFQH 106_ TVQLL 111_ VYAFP 116_ DQLTV 121_ SPAAL 126_ VPGDP 131_ EVACT 136_ AHKVT 141_ PVDPN 146_ ALSFS 151_ LLVGG 156_ QELEG 161_ AQALG 166_ PEVQE 171_ EEEEP 176_ QGDED 181_ VLFRV 186_ TERWR 191_ LPPLG 196_ TPVPP 201_ ALYCQ 206_ ATMRL 211_ PGLEL 216_ SHRQA 221_ IPVLH 226_ SPTSP 231_ EPPDT 236_ TSPES 241_ PDTTS 246_ PESPD 251_ TTSQE 256_ PPDTT 261_ SPEPP 266_ DKTSP 271_ EPAPQ 276_ QGSTH 281_ TPRSP 286_ GSTRT 291_ RRPEI 296_ SQAGP 301_ TQGEV 306_ IPTGS 311_ SKPAG 316_ DQLPA 321_ ALWTS 326_ SAVLG 331_ LLLLA 336_ LPTYH 341_ LWKRC 346_ RHLAE 351_ DDTHP 356_ PASLR 361_ LLPQV 366_ SAWAG 371_ LRGTG 376_QVGIS
1: Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding