Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1)
1_MNIVE 6_ NSIFL 11_ SNLMK 16_ SANTF 21_ ELKYD 26_ LSCEL 31_ YRMST 36_ YSTFP 41_ AGVPV 46_ SERSL 51_ ARAGF 56_ YYTGV 61_ NDKVK 66_ CFCCG 71_ LMLDN 76_ WKRGD 81_ SPTEK 86_ HKKLY 91_ PSCRF 96_ VQSLN 101_ SVNNL 106_ EATSQ 111_ PTFPS 116_ SVTNS 121_ THSLL 126_ PGTEN 131_ SGYFR 136_ GSYSN 141_ SPSNP 146_ VNSRA 151_ NQDFS 156_ ALMRS 161_ SYHCA 166_ MNNEN 171_ ARLLT 176_ FQTWP 181_ LTFLS 186_ PTDLA 191_ KAGFY 196_ YIGPG 201_ DRVAC 206_ FACGG 211_ KLSNW 216_ EPKDN 221_ AMSEH 226_ LRHFP 231_ KCPFI 236_ ENQLQ 241_ DTSRY 246_ TVSNL 251_ SMQTH 256_ AARFK 261_ TFFNW 266_ PSSVL 271_ VNPEQ 276_ LASAG 281_ FYYVG 286_ NSDDV 291_ KCFCC 296_ DGGLR 301_ CWESG 306_ DDPWV 311_ QHAKW 316_ FPRCE 321_ YLIRI 326_ KGQEF 331_ IRQVQ 336_ ASYPH 341_ LLEQL 346_ LSTSD 351_ SPGDE 356_ NAESS 361_ IIHFE 366_ PGEDH 371_ SEDAI 376_ MMNTP 381_ VINAA 386_ VEMGF 391_ SRSLV 396_ KQTVQ 401_ RKILA 406_ TGENY 411_ RLVND 416_ LVLDL 421_ LNAED 426_ EIREE 431_ ERERA 436_ TEEKE 441_ SNDLL 446_ LIRKN 451_ RMALF 456_ QHLTC 461_ VIPIL 466_ DSLLT 471_ AGIIN 476_ EQEHD 481_ VIKQK 486_ TQTSL 491_ QAREL 496_ IDTIL 501_ VKGNI 506_ AATVF 511_ RNSLQ 516_ EAEAV 521_ LYEHL 526_ FVQQD 531_ IKYIP 536_ TEDVS 541_ DLPVE 546_ EQLRR 551_ LQEER 556_ TCKVC 561_ MDKEV 566_ SIVFI 571_ PCGHL 576_ VVCKD 581_ CAPSL 586_ RKCPI 591_ CRSTI 596_KGTVR
1: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8