Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
1_MHKTA 6_ SQRLF 11_ PGPSY 16_ QNIKS 21_ IMEDS 26_ TILSD 31_ WTNSN 36_ KQKMK 41_ YDFSC 46_ ELYRM 51_ STYST 56_ FPAGV 61_ PVSER 66_ SLARA 71_ GFYYT 76_ GVNDK 81_ VKCFC 86_ CGLML 91_ DNWKL 96_ GDSPI 101_ QKHKQ 106_ LYPSC 111_ SFIQN 116_ LVSAS 121_ LGSTS 126_ KNTSP 131_ MRNSF 136_ AHSLS 141_ PTLEH 146_ SSLFS 151_ GSYSS 156_ LSPNP 161_ LNSRA 166_ VEDIS 171_ SSRTN 176_ PYSYA 181_ MSTEE 186_ ARFLT 191_ YHMWP 196_ LTFLS 201_ PSELA 206_ RAGFY 211_ YIGPG 216_ DRVAC 221_ FACGG 226_ KLSNW 231_ EPKDD 236_ AMSEH 241_ RRHFP 246_ NCPFL 251_ ENSLE 256_ TLRFS 261_ ISNLS 266_ MQTHA 271_ ARMRT 276_ FMYWP 281_ SSVPV 286_ QPEQL 291_ ASAGF 296_ YYVGR 301_ NDDVK 306_ CFCCD 311_ GGLRC 316_ WESGD 321_ DPWVE 326_ HAKWF 331_ PRCEF 336_ LIRMK 341_ GQEFV 346_ DEIQG 351_ RYPHL 356_ LEQLL 361_ STSDT 366_ TGEEN 371_ ADPPI 376_ IHFGP 381_ GESSS 386_ EDAVM 391_ MNTPV 396_ VKSAL 401_ EMGFN 406_ RDLVK 411_ QTVQS 416_ KILTT 421_ GENYK 426_ TVNDI 431_ VSALL 436_ NAEDE 441_ KREEE 446_ KEKQA 451_ EEMAS 456_ DDLSL 461_ IRKNR 466_ MALFQ 471_ QLTCV 476_ LPILD 481_ NLLKA 486_ NVINK 491_ QEHDI 496_ IKQKT 501_ QIPLQ 506_ ARELI 511_ DTILV 516_ KGNAA 521_ ANIFK 526_ NCLKE 531_ IDSTL 536_ YKNLF 541_ VDKNM 546_ KYIPT 551_ EDVSG 556_ LSLEE 561_ QLRRL 566_ QEERT 571_ CKVCM 576_ DKEVS 581_ VVFIP 586_ CGHLV 591_ VCQEC 596_ APSLR 601_ KCPIC 606_ RGIIK 611_GTVRT
1: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle