Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein)
1_MSGQS 6_ LTDRI 11_ TAAQH 16_ SVTGS 21_ AVSKT 26_ VCKAT 31_ THEIM 36_ GPKKK 41_ HLDYL 46_ IQCTN 51_ EMNVN 56_ IPQLA 61_ DSLFE 66_ RTTNS 71_ SWVVV 76_ FKSLI 81_ TTHHL 86_ MVYGN 91_ ERFIQ 96_ YLASR 101_ NTLFN 106_ LSNFL 111_ DKSGL 116_ QGYDM 121_ STFIR 126_ RYSRY 131_ LNEKA 136_ VSYRQ 141_ VAFDF 146_ TKVKR 151_ GADGV 156_ MRTMN 161_ TEKLL 166_ KTVPI 171_ IQNQM 176_ DALLD 181_ FNVNS 186_ NELTN 191_ GVINA 196_ AFMLL 201_ FKDAI 206_ RLFAA 211_ YNEGI 216_ INLLE 221_ KYFDM 226_ KKNQC 231_ KEGLD 236_ IYKKF 241_ LTRMT 246_ RISEF 251_ LKVAE 256_ QVGID 261_ RGDIP 266_ DLSQA 271_ PSSLL 276_ DALEQ 281_ HLASL 286_ EGKKI 291_ KDSTA 296_ ASRAT 301_ TLSNA 306_ VSSLA 311_ STGLS 316_ LTKVD 321_ EREKQ 326_ AALEE 331_ EQARL 336_ KALKE 341_ QRLKE 346_ LAKKP 351_ HTSLT 356_ TAASP 361_ VSTSA 366_ GGIMT 371_ APAID 376_ IFSTP 381_ SSSNS 386_ TSKLP 391_ NDLLD 396_ LQQPT 401_ FHPSV 406_ HPMST 411_ ASQVA 416_ STWGD 421_ PFSAT 426_ VDAVD 431_ DAIPS 436_ LNPFL 441_ TKSSG 446_ DVHLS 451_ ISSDV 456_ STFTT 461_ RTPTH 466_ EMFVG 471_ FTPSP 476_ VAQPH 481_ PSAGL 486_ NVDFE 491_ SVFGN 496_ KSTNV 501_ IVDSG 506_ GFDEL 511_ GGLLK 516_ PTVAS 521_ QNQNL 526_ PVAKL 531_ PPSKL 536_ VSDDL 541_ DSSLA 546_ NLVGN 551_ LGIGN 556_ GTTKN 561_ DVNWS 566_ QPGEK 571_ KLTGG 576_ SNWQP 581_ KVAPT 586_ TAWNA 591_ ATMAP 596_ PVMAY 601_ PATTP 606_ TGMIG 611_ YGIPP 616_ QMGSV 621_ PVMTQ 626_ PTLIY 631_ SQPVM 636_ RPPNP 641_ FGPVS 646_GAQIQ
1: Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:21808019, PubMed:22118466, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:24067654, PubMed:25241929)