Mediator of RNA polymerase II transcription subunit 21 (Mediator complex subunit 21) (RNA polymerase II holoenzyme component SRB7) (RNAPII complex component SRB7) (hSrb7)
1_MADRL 6_ TQLQD 11_ AVNSL 16_ ADQFC 21_ NAIGV 26_ LQQCG 31_ PPASF 36_ NNIQT 41_ AINKD 46_ QPANP 51_ TEEYA 56_ QLFAA 61_ LIART 66_ AKDID 71_ VLIDS 76_ LPSEE 81_ STAAL 86_ QAASL 91_ YKLEE 96_ ENHEA 101_ ATCLE 106_ DVVYR 111_ GDMLL 116_ EKIQS 121_ ALADI 126_ AQSQL 131_ KTRSG 136_THSQS
1: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors