Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III)
1_MREIV 6_ HIQAG 11_ QCGNQ 16_ IGAKF 21_ WEVIS 26_ DEHGI 31_ DPSGN 36_ YVGDS 41_ DLQLE 46_ RISVY 51_ YNEAS 56_ SHKYV 61_ PRAIL 66_ VDLEP 71_ GTMDS 76_ VRSGA 81_ FGHLF 86_ RPDNF 91_ IFGQS 96_ GAGNN 101_ WAKGH 106_ YTEGA 111_ ELVDS 116_ VLDVV 121_ RKECE 126_ NCDCL 131_ QGFQL 136_ THSLG 141_ GGTGS 146_ GMGTL 151_ LISKV 156_ REEYP 161_ DRIMN 166_ TFSVV 171_ PSPKV 176_ SDTVV 181_ EPYNA 186_ TLSIH 191_ QLVEN 196_ TDETY 201_ CIDNE 206_ ALYDI 211_ CFRTL 216_ KLATP 221_ TYGDL 226_ NHLVS 231_ ATMSG 236_ VTTSL 241_ RFPGQ 246_ LNADL 251_ RKLAV 256_ NMVPF 261_ PRLHF 266_ FMPGF 271_ APLTA 276_ RGSQQ 281_ YRALT 286_ VPELT 291_ QQMFD 296_ AKNMM 301_ AACDP 306_ RHGRY 311_ LTVAT 316_ VFRGR 321_ MSMKE 326_ VDEQM 331_ LAIQS 336_ KNSSY 341_ FVEWI 346_ PNNVK 351_ VAVCD 356_ IPPRG 361_ LKMSS 366_ TFIGN 371_ STAIQ 376_ ELFKR 381_ ISEQF 386_ TAMFR 391_ RKAFL 396_ HWYTG 401_ EGMDE 406_ MEFTE 411_ AESNM 416_ NDLVS 421_ EYQQY 426_ QDATA 431_ EEEGE 436_ MYEDD 441_EEESE
1: Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977)