Prepronociceptin [Cleaved into: Nocistatin; Nociceptin (Orphanin FQ) (PPNOC); Orphanin FQ2]
1_MKVLL 6_ CDLLL 11_ LSLFS 16_ SVFSS 21_ CQRDC 26_ LTCQE 31_ KLHPA 36_ LDSFD 41_ LEVCI 46_ LECEE 51_ KVFPS 56_ PLWTP 61_ CTKVM 66_ ARSSW 71_ QLSPA 76_ APEHV 81_ AAALY 86_ QPRAS 91_ EMQHL 96_ RRMPR 101_ VRSLF 106_ QEQEE 111_ PEPGM 116_ EEAGE 121_ MEQKQ 126_ LQKRF 131_ GGFTG 136_ ARKSA 141_ RKLAN 146_ QKRFS 151_ EFMRQ 156_ YLVLS 161_ MQSSQ 166_ RRRTL 171_HQNGN
1: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development
2: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia
3: Has potent analgesic activity