Aquaporin-6 (AQP-6) (Aquaporin-2-like) (Kidney-specific aquaporin) (hKID)
1_MDAVE 6_ PGGRG 11_ WASML 16_ ACRLW 21_ KAISR 26_ ALFAE 31_ FLATG 36_ LYVFF 41_ GVGSV 46_ MRWPT 51_ ALPSV 56_ LQIAI 61_ TFNLV 66_ TAMAV 71_ QVTWK 76_ ASGAH 81_ ANPAV 86_ TLAFL 91_ VGSHI 96_ SLPRA 101_ VAYVA 106_ AQLVG 111_ ATVGA 116_ ALLYG 121_ VMPGD 126_ IRETL 131_ GINVV 136_ RNSVS 141_ TGQAV 146_ AVELL 151_ LTLQL 156_ VLCVF 161_ ASTDS 166_ RQTSG 171_ SPATM 176_ IGISV 181_ ALGHL 186_ IGIHF 191_ TGCSM 196_ NPARS 201_ FGPAI 206_ IIGKF 211_ TVHWV 216_ FWVGP 221_ LMGAL 226_ LASLI 231_ YNFVL 236_ FPDTK 241_ TLAQR 246_ LAILT 251_ GTVEV 256_ GTGAG 261_ AGAEP 266_ LKKES 271_ QPGSG 276_AVEME
1: Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient (PubMed:8812490). Unlike classical aquaporins, AQP6 is an intracellular channel with selective anion permeability, particularly for nitrate, and exhibits very low water permeability (By similarity). It may also facilitate the transport of gases, such as CO2 and NH4(+), as demonstrated in vitro (By similarity)